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首页> 外文会议>International Conference on Biomedical Engineering >Rheumatoid Arthritis T-lymphocytes 'Immature' Phenotype and Attempt of its Correction in Go-culture with Human Thymic Epithelial Cells
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Rheumatoid Arthritis T-lymphocytes 'Immature' Phenotype and Attempt of its Correction in Go-culture with Human Thymic Epithelial Cells

机译：类风湿性关节炎T淋巴细胞“未成熟”表型及其对人胸腺上皮细胞的去培养中的矫正尝试

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We found that the level of CD3+4+8+T-cells was normal in peripheral blood of RA patients. Otherwise an amount of CD3+4-8-, CD3-4+ and CD3-8+ subpopulations was increased in 10 patients and level of CD10+ cells (24%) in 2. We found also significant imbalance of CD3+4+8- and CD3+4-8+ mature T-cells in all RA patients The level of CD3+4+ 5-40-fold exceeded the level of CD3+8+. The 24-hour incubation of RA patient's lymphocytes with human TEC culture and TEC supernatant could influence upon T-cell receptor phenotype. We found tendency to increase of CD3 after the incubation in all patients. Otherwise the dynamic of CD4 and CD8 was different. In 4 cases we saw the moderate decrease of CD4 expression and increase of CD8. But in 9 cases the imbalance of CD3+4+ and CD3+8+ subpopulations increased after cultivation due to progressive CD8 expression diminution. The above mentioned facts allowed us to suppose the heterogeneity of T-cell selection disturbances in RA
机译：我们发现CD3 + 4 + 8 + T细胞的水平在RA患者的外周血中是正常的。否则，在10名患者中增加了CD3 + 4-8-，CD3-4 +和CD3-8 +亚次次次蛋白酶和CD10 +细胞水平（24％）。我们发现CD3 + 4 + 8-的显着性失衡也是显着的所有RA患者的CD3 + 4-8 +成熟T细胞CD3 + 4 + 5-40倍的水平超过CD3 + 8 +水平。 RA患者淋巴细胞与人体TEC培养和TEC上清液的24小时孵育可能影响T细胞受体表型。我们发现所有患者孵育后CD3增加的倾向。否则CD4和CD8的动态不同。在4例中，我们看到CD4表达和CD8增加的中度降低。但在9例中，由于渐进的CD8表达减少，培养后CD3 + 4 +和CD3 + 8 +亚群的不平衡增加。上述事实使我们能够假设RA中T细胞选择干扰的异质性

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