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首页> 外文会议>Society for Free Radical Research International >Radiomodulating Effect of Tocotrienols: Possible Mechanisms and Potential Applications
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Radiomodulating Effect of Tocotrienols: Possible Mechanisms and Potential Applications

机译：Tocotrienols的放射性调节作用：可能的机制和潜在应用

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摘要

Ionizing radiation is an important source of oxidative stress in biological systems. Its deleterious effects in cells are mediated by reactive oxygen species leading to cell death or mutations in normal cells. It is routinely used for treatment of different types of tumors. Protection of normal tissues and sensitization of tumor cells to radiation remains a challenging task. Hence, natural compounds capable of modulating radiation effects will have potential benefits. Vitamin E is a generic term used for tocopherols and tocotrienols. Both tocopherols and tocotrienols exist as alpha, beta,gamma and delta forms. Tocotrienols occupy a special place among the vitamin E group of compounds due to their unique chemical structure and properties. Tocopherols and tocotrienols differ structurally in that tocopherols contain a saturated phytyl chain, and tocotrienols possess an unsaturated side chain attached to 1 -position on the chroman ring. Tocotrienols are primarily derived from oat, wheat germ, barley, rye, rice bran and palm oil. It is reported that tocotrienols exert more significant effects than tocopherols due to higher accumulation of tocotrienols in the cells than tocopherols (Sen et al., 2006).
机译：电离辐射是生物系统中氧化应激的重要来源。其在细胞中的有害作用是通过导致正常细胞中细胞死亡或突变的反应性氧物质介导的。它经常用于治疗不同类型的肿瘤。保护正常组织和肿瘤细胞对辐射的敏化仍然是一个具有挑战性的任务。因此，能够调节辐射效应的天然化合物将具有潜在的益处。维生素E是用于生育酚和Tocotrienols的通用术语。生育酚和Tocotrienols都存在作为α，β，γ和δ形式。由于其独特的化学结构和性能，Tocotrienols占据了维生素E组化合物中的特殊位置。在结构上，生育酚和生育酚在结构上含有饱和植物链，Tocotrienols在铬环上附着于1位的不饱和侧链。 Tocotrienols主要来自燕麦，小麦胚芽，大麦，黑麦，米糠和棕榈油。据据悉，由于细胞中的细胞中的TOCOTRINOLS的积累率高于生育酚（Sen等，2006），据报道，Tocotrienols比生育酚更高的效果。

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