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首页> 外文会议>Society for Free Radical Research International >Identification of a Novel Spin Trapped Carbon-centered Radical from COX-catalyzed Peroxidation of Arachidonic Acid:LC/ESR and LC/MS Study
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Identification of a Novel Spin Trapped Carbon-centered Radical from COX-catalyzed Peroxidation of Arachidonic Acid:LC/ESR and LC/MS Study

机译：来自Cox催化的花生酸过氧化的新型旋转型碳含量的基团：LC / ESR和LC / MS研究

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摘要

COX-catalyzed peroxidation of arachidonic acid (AA) is a well known free radical reaction. Due to the lack of appropriate methodologies, however, no direct evidence has previously been found for either the formation of COX-mediated free radicals or their associated bioactivities. In order to advance the knowledge of COX-peroxidation, a combination of LC/ESR and LC/MS was used with a spin trap, alpha-[4-pyridyl-l-oxide]-N-rerr-butyl nitrone (POBN), to characterize the carbon-centered radicals formed from COX-catalyzed AA peroxidation in vitro. A total of three types of spin trapped free radicals were characterized, all stemming from PGF_2-type alkoxyl radicals via either (3-scissions or structure rearrangement. A special (3-scission was therefore proposed for the formation of a novel radical which has its electron centered on C=C bond nearby PGF ring. Our results advanced our knowledge of COX-catalyzed lipid peroxidation and will assist our ongoing study of COX-related bioactivities.
机译：Cox催化的花生酸（AA）过氧化是众所周知的自由基反应。然而，由于缺乏适当的方法，先前没有发现COX介导的自由基或其相关生物活性的形成。为了推进COX过氧化的知识，LC / ESR和LC / MS的组合与旋转阱，α-[4-吡啶基-L-L-氧化物] -N-RER-BUTYL NITRONE（POBN）一起使用，表征由Cox催化AA过氧化形成的碳中心基团体外。表征了三种类型的自旋捕获的自由基，均通过（3刻或结构重排液）由PGF_2型烷氧基自由基源自PGF_2型烷氧基。因此，提出了一种特殊的（3次侦察，用于形成具有其的新型自由基Electron以C = C键在PGF环附近的C = C键。我们的结果介绍了我们对Cox催化的脂质过氧化的了解，并有助于我们对Cox相关的生物活跃的持续研究。

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