SEROTONIN RECEPTOR AND SEROTONIN REUPTAKE TRANSPORTER EXPRESSION IN PRIMARY AND METASTATIC CANINE OSTEOSARCOMA CELL LINES.

机译：血清素受体和血清素再摄取转运蛋白表达在原发性和转移性犬骨瘤细胞系中。

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Serotonin (5-Hydroxytryptamine [5-HT]) receptors belong to the G-protein mediated receptor super-family. Their metabolic effects on neural, muscular, and endothelial tissues are well known. However, their role in bone is not well defined. Recently, both 5-HT and 5-Hydroxytryptamine transporter (5-HTT) have been identified in human and rat osteoblasts and osteocytes. These observations suggest that these proteins could be present and play a role in bone cancers. The purpose of this study was to determine if the 5-HT receptor system is present in canine osteosarcoma (OSA) cells and its potential as a novel therapeutic target.

机译：血清素（5-羟基 - 羟基胺[5-HT]）受体属于G蛋白介导的受体超级家族。它们对神经，肌肉和内皮组织的代谢效应是众所周知的。然而，它们在骨中的作用并不明确。最近，在人和大鼠成骨细胞和骨细胞中鉴定了5-HT和5-羟基三丁胺转运蛋白（5-HTT）。这些观察结果表明这些蛋白质可以存在并在骨癌中发挥作用。本研究的目的是确定5-HT受体系统是否存在于犬Osteosarcoma（OSA）细胞中及其作为新的治疗靶标的潜力。

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《Annual conference of the Veterinary Cancer Society》|2008年||共1页
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Shay Bracha; Kenine E Comstock; Evan T Keller; Toru Ishi; Richard Walshaw; Joyce E Obradovich;
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1. Expression of serotonin, chromogranin-A, serotonin receptor-2B, tryptophan hydroxylase-1, and serotonin reuptake transporter in the intestine of dogs with chronic enteropathy [J] . Bailey Candice, Ruaux Craig, Stang Bernadette V., Journal of Veterinary Diagnostic Investigation . 2016,第3期

机译：慢性肠病犬肠中5-羟色胺，嗜铬粒蛋白-A，5-羟色胺受体-2B，色氨酸羟化酶-1和5-羟色胺再摄取转运蛋白的表达
2. 13-cis-Retinoic acid alters intracellular serotonin, increases 5-HT1A receptor, and serotonin reuptake transporter levels in vitro. [J] . OReilly KC, Trent S, Bailey SJ, Experimental Biology and Medicine: Journal of the Society for Experimental Biology and Medicine . 2007,第9期

机译：13-顺式视黄酸在体外可改变细胞内5-羟色胺，增加5-HT1A受体和5-羟色胺再摄取转运蛋白水平。
3. Expression of serotonin receptors and role of serotonin in human prostate cancer tissue and cell lines. [J] . Dizeyi N, Bjartell A, Nilsson E, The Prostate . 2004,第3期

机译：血清素受体的表达及其在人前列腺癌组织和细胞系中的作用。
4. SEROTONIN RECEPTOR AND SEROTONIN REUPTAKE TRANSPORTER EXPRESSION IN PRIMARY AND METASTATIC CANINE OSTEOSARCOMA CELL LINES. [C] . Shay Bracha, Kenine E Comstock, Evan T Keller, Annual conference of the Veterinary Cancer Society . 2008

机译：血清素受体和血清素再摄取转运蛋白表达在原发性和转移性犬骨瘤细胞系中。
5. Serotonin Receptor Signaling Following Selective Serotonin Reuptake Inhibitor Treatment or: How I Learned to Stop Worrying and Love the Agonist. [D] . Van Dyke, Adam M. 2016

机译：选择性5-羟色胺再摄取抑制剂治疗后的5-羟色胺受体信号，或：我如何学会停止担心和热爱激动剂。
6. The expression and role of serotonin receptor 5HTR2A in canine osteoblasts and an osteosarcoma cell line [O] . Shay Bracha, Austin Viall, Cheri Goodall, 2013

机译：血清素5HTR2A在犬成骨细胞和骨肉瘤细胞系中的表达及作用
7. Immunohistochemically characterization of serotonin reuptake transporter; 5-HT1B, 5-HT2A, 5-HT2B receptors, and tryptophan-5-hydroxylase expression in normal human hearts [O] . Teresa Neri-Gomez, Guillermo Valero-Elizondo, Armando Mansilla-Olivares, 2018

机译：免疫组织化学表征血清素再摄取转运蛋白; 5-HT1B，5-HT2A，5-HT2B受体，以及正常人体心中的色氨酸-5-羟化酶表达

SEROTONIN RECEPTOR AND SEROTONIN REUPTAKE TRANSPORTER EXPRESSION IN PRIMARY AND METASTATIC CANINE OSTEOSARCOMA CELL LINES.

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