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A bolus low dose Dexmedetomidine As An Anaesthetic Adjuvant

机译:推注低剂量Dexmedetomidine作为麻醉佐剂

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Dexmedetomidine is an excellent anaesthetic adjuvant when given as a continuous infusion intraoperatively. We predict that as a low bolus dose it should be as effective. 60 patients scheduled for orthopaedic limb surgeries were randomized in a double blind manner either dexmedetomidine 0.5 ng/kg IV bolus (Group A=30) or saline placebo (Group B=30) 10 minutes before induction. BP AND HR were similar in both groups (p>0.05). After 60 minutes, Group A versus Group B showed that sevoflurane requirement was markedly reduced by 39% (0.63+-0.07 vs 1.03+-0.11, P<0.001) and MAC was reduced by 43% (0.58+-0.06 vs 1.02+-0.09, P<0.001). Morphine requirement intraoperatively was also different between the two groups ( 2.7+-1.0 vs 8.6+-2.0, P<0.05). Mean extubation time was similar for both groups. Pain score and rescue fentanyl requirements were less in Group A before discharge to the ward(p<0.05).A low bolus dexmedetomidine is a useful anaesthetic adjuvant for surgeries lasting 1-2 hours(values mean+-SD).
机译:当术中作为连续输注给出时,Dexmedetomidine是一种优异的麻醉剂佐剂。我们预测,作为低推注剂量,它应该有效。 60例针对整形外科肢体手术的患者以双盲方式随机化Dexmedetomidine 0.5ng / kg IV诱导(A = 30)或盐水排放剂(B = 30)10分钟诱导前10分钟。 BP和HR在两组中相似(P> 0.05)。 60分钟后,A组对B组显示,七氟醚要求明显减少39%(0.63±0.07 vs 1.03 + -0.11,P <0.001)和Mac减少43%(0.58 + -0.06 Vs 1.02 + - 0.09,p <0.001)。两组(2.7 + -1.0Vs 8.6 + -2.0,P <0.05)之间的吗啡需求也不同。两个组的平均拔管时间相似。在排放到病房之前,A组A疼痛评分和救援芬太尼要求较少(P <0.05)。低推注探测咪腺嘌呤是持续1-2小时的手术的有用麻醉剂佐剂(值平均值+ -SD)。

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