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More is better - Reviewing the science behind duration of antimicrobial therapy

机译：更多更好 - 审查抗菌治疗持续时间后的科学

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Antimicrobial resistance concerns have created a renewed interest in antimicrobial stewardship programs in both human and veterinary medicine. Due to the associated logistical and administrative burdens, formal antimicrobial stewardship programs haveseen limited adoption outside of large institutional care centers. However, one of the key components of these programs is to optimize antimicrobial therapy - administration: of the right drug, to the right patient, at the right dose, by the right route,for the right duration. Optimizing dosing regimens does not have the same logistical burdens as a formal program, it simply requires evidential support and implementation by individual clinicians; which begs the question, "what is the basis for our current duration of antibiotic therapy recommendations?". To answer this question, a literature search was conducted to evaluate the scientific basis to support current recommendations for duration of therapy in veterinary medicine. Overall, the quantity andquality of scientific studies to support a specific duration of therapy for a specific antimicrobial was underwhelming. However, the limited data generally supports the assumption that shorter durations of therapy can be effective and should be more thoroughly investigated.
机译：抗微生物抗性问题在人类和兽医中产生了对抗微生物管道方案的重新感兴趣。由于相关的后勤和行政负担，正式的抗微生物管理计划在大型制度护理中心之外存在有限的采用。然而，这些程序的关键组分之一是优化抗菌治疗 - 给药：右侧药物，右侧剂量，在正确的持续时间内以正确的患者进行右侧剂量。优化给药方案没有与正式计划相同的后勤负担，它只是要求单独的临床医生的证据支持和实施;这引出了问题，“我们目前的抗生素治疗建议持续时间是什么？”。为了回答这个问题，进行了文学搜索，以评估科学依据，以支持当前兽医治疗持续时间的建议。总的来说，科学研究的数量和支持特异性抗菌药物治疗持续时间的数量和质量在很大程度上。然而，有限的数据通常支持假设较短的治疗持续时间可以有效，应该更彻底地研究。

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