Uterine leiomyosarcoma (ULMS) is an uncommon malignant tumor that accounts for less than one-third of uterine sarcomas and approximately 1% of uterine malignancies. Cases of local and distant ULMS metastasis have been widely reported, especially to the lungs. There have been very few cases, however, of ULMS metastasis to the upper gastrointestinal (Gl) tract published in the peer-reviewed literature. Here we describe a case of biopsy-proven ULMS metastasis to the first part of the duodenum, representing the third reported case of its kind. Theories regarding presentation, treatment, clinical course, and outcome of patients with ULMS metastasis to the duodenum are presented.
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