High Sensitive Derivatization Method for the Analysis of Alendronic Acid in Human EDTA Plasma by LC/MS/MS.

机译：LC / MS / MS对人EDTA血浆中醇酸分析的高敏感衍生化方法。

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The derivatization step is mandatory in biphosphonate LC/MS/MS analyses. Due to their multi-charged states, a high sensitivity and selective assay is impossible without derivatization. By methylation of the amine and phosphonate groups, a signal to noise ratio of 29 was obtained for a LLOQ of 50 pg/mL with this method. Clinical study samples were analysed with this assay which was shown to be accurate, precise and reproducible.

机译：衍生化步骤是在二膦酸盐LC / MS / MS分析中的强制性。由于它们的多重指出，不衍生化不可能进行高灵敏度和选择性测定。通过胺和膦酸酯基团的甲基化，通过该方法获得50pg / ml的LLOQ的噪声比的信号。通过该测定分析临床研究样品，该测定显示为准确，精确和可重复。

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《American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics》|2009年||共1页
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Nicolas Jean; Chantal Gravel; Sylvain Lachance; Ann Levesque; Robert Masse;
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中图分类 TB994.5-53;
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1. Development of a sensitive bioanalytical method for determination of PNU-83757 in rat, monkey and human plasma: from LC-UV to LC-MS/MS. [J] . Zhong W Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis . 2002,第3期

机译：建立灵敏的生物分析方法测定大鼠，猴和人血浆中的PNU-83757：从LC-UV到LC-MS / MS。
2. On-cartridge derivatization coupled with solid-phase extraction for the ultra-sensitive determination of minodronic acid in human plasma by LC-MS/MS method [J] . Yang Yong, Liu Cai, Zhang Yifan, Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis . 2015,第Null期

机译：盒内衍生化与固相萃取相联用于LC-MS / MS法超灵敏测定人血浆中的米诺膦酸
3. A rapid and sensitive method for determination of veliparib (ABT-888), in human plasma, bone marrow cells and supernatant by using LC/MS/MS. [J] . Reinhardt S, Zhao M, Mnatsakanyan A, Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis . 2010,第1期

机译：使用LC / MS / MS快速，灵敏的方法测定人血浆，骨髓细胞和上清液中的维利帕瑞（ABT-888）。
4. High Sensitive Derivatization Method for the Analysis of Alendronic Acid in Human EDTA Plasma by LC/MS/MS. [C] . Nicolas Jean, Chantal Gravel, Sylvain Lachance, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2009

机译：LC / MS / MS对人EDTA血浆中醇酸分析的高敏感衍生化方法。
5. Derivatization Methods for Improved Metabolome Analysis by LC-MS/MS [D] . Malec, Paige A. 2018

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6. Development and Validation of a Highly Sensitive LC-MS/MS Method for the Analysis of Bile Acids in Serum Plasma and Liver Tissue Samples [O] . Cristina Gómez, Simon Stücheli, Denise V. Kratschmar, 2020

机译：高敏感LC-MS / MS方法的开发和验证用于分析血清血浆和肝组织样品中的胆汁酸
7. A SENSITIVE BIO ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF RUCAPARIB IN HUMAN PLASMA BY LC-ESI-MS/MS. [O] . Vamseekrishna Gorijavolu 2018

机译：LC-ESI-MS / MS对人血浆中Rucaparib的敏感生物分析方法开发和验证。

High Sensitive Derivatization Method for the Analysis of Alendronic Acid in Human EDTA Plasma by LC/MS/MS.

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