LC/MS~(E) label-free quantitative proteomic analysis of purified invasive versus non-invasive Plasmodium falciparum merozoites in support of malaria vaccine development

机译：LC / MS〜（e）无标菌定量蛋白质组学分析纯化的侵入性与非侵入性疟原虫Merozoites支持疟疾疫苗发育

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First combined qualitative and quantitative assessment of P. falciparum HD and HHSS parasite lines. Demonstrates LC/MSE label-free quantitative approach was robust and reproducible. RBC invasion associated merozoite proteins were identified in independent merozoite samples with increased protein concentrations. Other merozoite proteins with known and unknown functions were identified with an increased or decreased protein concentration. Selected merozoite proteins will be further evaluated for target validation, more specifically, direct association with a long-lived merozoite phenotype.

机译：第一种组合定性和定量评估P. falciparum HD和HHSS寄生虫线。展示LC / MSE标签的定量方法是稳健和可重复的。 RBC侵袭相关的Merozoite蛋白在独立的Merozoite样品中鉴定出具有增加的蛋白质浓度。用蛋白质浓度增加或降低，鉴定了具有已知和未知功能的其他Merozoite蛋白。选择的MeRozoite蛋白将进一步评估目标验证，更具体地，与长期的Merozoite表型直接联合。

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《American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics》|2010年||共1页
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Krishan Kumar; Michael J. Nold; J. David Haynes; Prakash Srinivasan; J. Kathleen Moch; Karine Reiter; David L. Narum;
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1. Development and pre-clinical analysis of a Plasmodium falciparum Merozoite Surface Protein-1(42) malaria vaccine. [J] . Angov E, Aufiero BM, Turgeon AM, Molecular and Biochemical Parasitology . 2003,第2期

机译：恶性疟原虫裂殖子表面蛋白-1（42）疟疾疫苗的开发和临床前分析。
2. Functional analysis of Plasmodium falciparum merozoite antigens: implications for erythrocyte invasion and vaccine development [J] . Cowman AF., Baldi DL., Duraisingh M., Philosophical Transactions of the Royal Society of London, Series B. Biological Sciences . 2002,第1417期

机译：恶性疟原虫裂殖子抗原的功能分析：对红细胞入侵和疫苗开发的影响
3. Identification and prioritization of merozoite antigens as targets of protective human immunity to Plasmodium falciparum malaria for vaccine and biomarker development [J] . RichardsJ.S., ArumugamT.U., ReilingL., The Journal of Immunology: Official Journal of the American Association of Immunologists . 2013,第2期

机译：鉴定和优先确定裂殖子抗原作为保护人对恶性疟原虫疟疾的保护性免疫的靶标，以开发疫苗和生物标记物
4. LC/MS~(E) label-free quantitative proteomic analysis of purified invasive versus non-invasive Plasmodium falciparum merozoites in support of malaria vaccine development [C] . Krishan Kumar, Michael J. Nold, J. David Haynes, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：LC / MS〜（e）无标菌定量蛋白质组学分析纯化的侵入性与非侵入性疟原虫Merozoites支持疟疾疫苗发育
5. Development of a Viral Vaccine Vector Expressing a Plasmodium falciparum Erythrocyte Membrane Protein Domain to Target Severe Malaria [D] . Crager, Sara Eve 2011

机译：表达表达疟原虫红细胞膜蛋白结构膜蛋白域的病毒疫苗载体以靶向严重疟疾
6. Functional analysis of Plasmodium falciparum merozoite antigens: implications for erythrocyte invasion and vaccine development. [O] . Alan F Cowman, Deborah L Baldi, Manoj Duraisingh, 2002

机译：恶性疟原虫裂殖子抗原的功能分析：对红细胞入侵和疫苗开发的影响。
7. Improved LC-MS chromatographic alignment increases the accuracy of label-free quantitative proteomics: Comparison of spectral counting versus ion intensity-based proteomic quantification strategies [O] . Daniel H.J. Ng, Jonathan D. Humphries, Julian N. Selley, 2017

机译：改进的LC-MS色谱对准增加了无标签定量蛋白质组学的准确性：光谱计数与离子强度的蛋白质组学定量策略的比较
8. Analysis of Variation in PF83, an Erythrocytic Merozoite Vaccine CandidateAntigen of Plasmodium falciparum [R] . Thomas, A. W., Waters, A. P., Carr, D. 1990

机译：恶性疟原虫红细胞裂殖子疫苗候选抗原pF83的变异分析

LC/MS~(E) label-free quantitative proteomic analysis of purified invasive versus non-invasive Plasmodium falciparum merozoites in support of malaria vaccine development

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