METABOLOMIC STUDY OF ADONIFOLINE, A PYRROLIZIDINE ALKALOID, INDUCED HEPATOTOXICITY IN RATS BY UPLC/OATOF MS~(E)

机译：吡咯嗪的代谢物研究，吡咯烷生物碱，UPLC / OATOF MS〜（e）的大鼠肝毒性

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The present study was the first attempt of the metabolomics study of HPA-induced hepatotoxicity and identification of potential biomarkers related with toxicity. Generic UPLC/oaTOF MS~(E)/MarkerLynx XS for sample profiling strategy is fast and efficient. MS~(E) data offers fragment information for identify confirmation and structural elucidation.

机译：本研究是首次尝试HPA诱导的HPA肝毒性和鉴定与毒性有关的潜在生物标志物的尝试。用于样品分析策略的通用UPLC / OATOF MS〜（e）/ Markerlynx XS快速有效。 MS〜（e）数据提供识别确认和结构阐释的片段信息。

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《American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics》|2010年||共1页
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Li Yang; Aizhen Xiong; Xiuli Wang; Swee Lee Yap; Kate Yu; Zhengtao Wang;
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1. The comparative pharmacokinetics of two pyrrolizidine alkaloids, senecionine and adonifoline, and their main metabolites in rats after intravenous and oral administration by UPLC/ESIMS [J] . Wang C., Li Y., Gao J., Analytical and bioanalytical chemistry . 2011,第1期

机译：通过UPLC / ESIMS静脉内和口服给药后，两种吡咯嗪核苷生物碱，芥子碱和阿多福林及其主要代谢产物在大鼠中的比较药代动力学
2. The comparative pharmacokinetics of two pyrrolizidine alkaloids, senecionine and adonifoline, and their main metabolites in rats after intravenous and oral administration by UPLC/ESIMS [J] . Changhong Wang, Yan Li, Jiangguo Gao, Analytical and Bioanalytical Chemistry . 2011,第1期

机译：UPLC / ESIMS静脉内和口服给药后，两种吡咯嗪核苷生物碱，芥子碱和阿多福林及其主要代谢产物在大鼠体内的比较药代动力学
3. UPLC/MS/MS-Based Metabolomics Study of the Hepatotoxicity and Nephrotoxicity in Rats Induced by Polygonum multiflorum Thunb. [J] . Yan Yan, Ning Shi, Xuyang Han, ACS Omega . 2020,第18期

机译：基于UPLC / MS / MS的代谢组合研究培养型植物诱导大鼠肝毒性和肾毒性。
4. METABOLOMIC STUDY OF ADONIFOLINE, A PYRROLIZIDINE ALKALOID, INDUCED HEPATOTOXICITY IN RATS BY UPLC/OATOF MS~(E) [C] . Li Yang, Aizhen Xiong, Xiuli Wang, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：吡咯嗪的代谢物研究，吡咯烷生物碱，UPLC / OATOF MS〜（e）的大鼠肝毒性
5. In Vitro and In Vivo Study of Pyrrolizidine Alkaloids-Induced Hepatotoxicity. [D] . Li, Yanhong. 2011

机译：吡咯烷核生物碱诱导的肝毒性的体外和体内研究。
6. UPLC/MS/MS-Based Metabolomics Study of the Hepatotoxicityand Nephrotoxicity in Rats Induced by Polygonum multiflorum Thunb. [O] . Yan Yan, Ning Shi, Xuyang Han, 2020

机译：基于UPLC / MS / MS的肝毒性代谢组学研究何首乌诱导的大鼠肾毒性和肾毒性
7. Hepatotoxic pyrrolizidine alkaloids induce DNA damage response in rat liver in a 28-day feeding study [O] . Johanna Ebmeyer, Josef Daniel Rasinger, Jan G. Hengstler, 2020

机译：肝毒性吡咯戊烷生物碱在28天喂养研究中诱导大鼠肝脏的DNA损伤反应

METABOLOMIC STUDY OF ADONIFOLINE, A PYRROLIZIDINE ALKALOID, INDUCED HEPATOTOXICITY IN RATS BY UPLC/OATOF MS~(E)

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