Mass spectrometric identification and characterization of cytochrome P4502D6 inhibitors from black cohosh (Actaea racemosa L.)

机译：黑色宿源（Actaea Haremosa L.）细胞色素P4502D6抑制剂的质谱鉴定及表征。

获取原文

页面导航

摘要
著录项
相似文献
相关主题

摘要

Black cohosh contains compounds that can inhibit cytochrome P4502D6. Mass spectrometric dereplication of the active fraction led to identification of two protopine-type alkaloids, protopine and allocryptopine, as potent inhibitors of CYP2D6. This is the first report that black cohosh contains protopine class of alkaloids. Both compounds were competitive inhibitors of CYP2D6 with Ki values of 72 nM and 110 nM for protopine and allocryptopine, respectively. The levels of these compounds in the crude black cohosh extract were low indicating that clinically relevant inhibition of CYP2D6 is unlikely to be observed. However, given the high activity of these compounds, extracts prepared by other procedures should be evaluated for content of these alkaloids to determine their potential to interact with drugs that are metabolized by CYP2D6.

机译：黑色Cohosh含有可以抑制细胞色素P4502D6的化合物。具有活性级分的质谱绝明，导致鉴定两种突出型生物碱，刺激素和Allocryptopine，作为CYP2D6的有效抑制剂。这是第一份报告，黑色·科学含有癌症类别的生物碱类。两种化合物分别是CYP2D6的竞争性抑制剂，其分别具有72nm和110nm的Ki值，分别用于原卟啉和Allocryptopine。粗黑色旋疗提取物中这些化合物的水平低表明，不太可能观察到CYP2D6的临床相关抑制。然而，考虑到这些化合物的高活性，应评估其他方法制备的提取物用于这些生物碱的含量，以确定它们与CYP2D6代谢的药物相互作用的潜力。

著录项

来源
《American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics》|2010年||共1页
会议地点
作者
Dejan Nikolic; Jinghu Li; Tanja Godecke; Shao-Nong Chen; Guido F. Pauli; Richard B. van Breemen;
展开▼
作者单位

展开▼
会议组织
原文格式 PDF
正文语种
中图分类 TB994.5-53;
关键词

相似文献

外文文献
专利

1. Alternative approach to species identification of Actaea racemosa L. (syn. Cimicifuga racemosa (L.) Nutt., black cohosh) herbal starting material: UV spectroscopy coupled with LDA [J] . Bittner Marian, Schenk Regina, Melzig Matthias F. Phytochemistry Letters . 2016,第Null期

机译：草药Actaea racemosa L.（Syn。Cimicifuga racemosa（L.）Nutt。，黑升麻）物种识别的替代方法草药起始原料：UV光谱结合LDA
2. MS, NMR, and DNA barcoding, complementary methods for identification and authentication of Black Cohosh (Actaea racemosa L.) [J] . Harnly J., Chen P., Colson K., Planta medica: Natural products and medicinal plant research . 2015,第11期

机译：MS，NMR和DNA条形码，互补方法，用于鉴定和认证Black Cohosh（Actaea Racemosa L.）
3. Gene identification in black cohosh (Actaea racemosa L.): expressed sequence tag profiling and genetic screening yields candidate genes for production of bioactive secondary metabolites [J] . Spiering Martin J., Urban Lori A., Nuss Donald L., Plant Cell Reports . 2011,第4期

机译：黑升麻（Actaea racemosa L.）中的基因鉴定：表达的序列标签分析和遗传筛选产生了具有生物活性次生代谢产物的候选基因
4. Mass spectrometric identification and characterization of cytochrome P4502D6 inhibitors from black cohosh (Actaea racemosa L.) [C] . Dejan Nikolic, Jinghu Li, Tanja Godecke, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：黑色宿源（Actaea Haremosa L.）细胞色素P4502D6抑制剂的质谱鉴定及表征。
5. Polyphenolic constituents from black cohosh (Actaea racemosa) and related species. [D] . Nuntanakorn, Paiboon. 2005

机译：黑升麻（Actaea racemosa）和相关物种的多酚成分。
6. Mass spectrometric dereplication of nitrogen-containing constituents of black cohosh (Cimicifuga racemosa L.) [O] . Dejan Nikolić, Tanja Gödecke, Shao-Nong Chen, -1

机译：黑轴（CIMICIFUGA HACEMOSA L.）的含氮成分的质谱全体性
7. Mass spectrometric dereplication of nitrogen-containing constituents of black cohosh (Cimicifuga racemosa L.) [O] . Dejan Nikolić, Tanja Gödecke, Shao-Nong Chen, 2012

机译：黑轴（CIMICIFUGA HACEMOSA L.）的含氮成分的质谱全体性

Mass spectrometric identification and characterization of cytochrome P4502D6 inhibitors from black cohosh (Actaea racemosa L.)

摘要

著录项

相似文献

相关主题

期刊订阅