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Multiple Reaction Monitoring MS Protein Analysis of Formalin-Fixed Paraffin-Embedded Tissue

机译:多重反应监测福尔马林固定石蜡包埋组织的MS蛋白质分析

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Equivalent CVs obtained during MRM analysis of peptides from frozen and FFPE tissue. Equivalent CVs obtained during MRM analysis of Iysine and arginine C-terminal peptides in FFPE tissue. Peak areas generally lower for peptides derived from FFPE tissue compared to frozen. FFPE tissues are amenable to quantitative proteomic analysis and the method can be applied to measurement of clinically relevant biomarker levels in archival tissue.
机译:在冷冻和FFPE组织的肽MRM分析期间获得的等效CV。在FFPE组织中肝脏和精氨酸C末端肽的MRM分析期间获得的等效CV。与冷冻相比,峰面积通常衍生自FFPE组织的肽。 FFPE组织均可用于定量蛋白质组学分析,并且该方法可以应用于归档组织中临床相关的生物标志物水平的测量。

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