Substrate Selectivity and Mechanism of the picNuA4 Histone Acetyltransferase Enzyme Complex as Revealed by Isotopic Labeling and LC-MS/MS

机译：PICNUA4组氨酸乙酰转移酶酶复合物的基板选择性和机制如同位素标记和LC-MS / MS所示

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(1) Histone modifications are responsible for regulation of diverse cellular processes such as gene transcription. (2) picNuA4 contains Esa1, an essential yeast acetyltransferase responsible for histone H4 acetylation. (3) Here we show: (a) Nucleosome structure restricts picNuA4 histone acetylation; (b) picNuA4 utilizes a dissociative mechanism for H4 acetylation; (c) picNuA4 acetylation order of H4 is random with slight preference for N-terminal lysine residues; (d) Multiple lysine residues of H4 are dispensible for efficient acetylation by picNuA.

机译：（1）组蛋白修饰负责调节不同细胞过程，例如基因转录。（2）PICNUA4含有ESA1，一种原始酵母乙酰转移酶，负责组蛋白H4乙酰化。（3）我们展示：（a）核心结构限制PICNUA4组蛋白乙酰化; （b）PICNUA4利用分离机制进行H4乙酰化; （c）H4的PICNUA4乙酰化顺序随机偏好于N-末端赖氨酸残基; （d）H4的多个赖氨酸残基可分配用于通过PICNUA有效乙酰化。

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《American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics》|2011年||共1页
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Susan Lee; Kevin M. Arnold; John M. Denu;
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1. Processing Mechanism and Substrate Selectivity of the Core NuA4 Histone Acetyltransferase Complex [J] . Kevin M. Arnold Susan Lee and John M. Denu Biochemistry . 2011,第5期

机译：核心NuA4组蛋白乙酰转移酶复合物的加工机理和底物选择性
2. Processing Mechanism and Substrate Selectivity of the Core NuA4 Histone Acetyltransferase Complex [J] . Arnold KM, Lee S, Denu JM Biochemistry . 2011,第5期

机译：核心NuA4组蛋白乙酰转移酶复合物的加工机理和底物选择性
3. Differential Peptide Labeling (iTRAQ) in LC-MS/MS Based Proteomics in Daphnia Reveal Mechanisms of an Antipredator Response [J] . Effertz Christoph, Mueller Stefan, von Elert Eric Journal of proteome research . 2015,第2期

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4. Substrate Selectivity and Mechanism of the picNuA4 Histone Acetyltransferase Enzyme Complex as Revealed by Isotopic Labeling and LC-MS/MS [C] . Susan Lee, Kevin M. Arnold, John M. Denu American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：PICNUA4组氨酸乙酰转移酶酶复合物的基板选择性和机制如同位素标记和LC-MS / MS所示
5. High Throughput Automated Comparative Analysis of RNAs Using Isotope Labeling and LC-MS/MS. [D] . Li, Siwei. 2014

机译：使用同位素标记和LC-MS / MS进行RNA的高通量自动化比较分析。
6. Processing mechanism and substrate selectivity of the core NuA4 histone acetyltransferase complex [O] . Kevin M. Arnold, Susan Lee, John M. Denu -1

机译：加工机构和所述芯Nua4组蛋白的底物选择性乙酰转移酶复合物
7. Combined Metabolic and Chemical (CoMetChem) Labeling Using Stable Isotopes – a Strategy to Reveal Site-Specific Histone Acetylation and Deacetylation Rates by LC-MS [O] . Alienke van Pijkeren, Jörn Dietze, Alejandro Sánchez Brotons, 2021

机译：使用稳定同位素组合代谢和化学（Cometchem）标记 - 一种揭示LC-MS的特异性特异性组蛋白乙酰化和脱乙酰化率的策略

Substrate Selectivity and Mechanism of the picNuA4 Histone Acetyltransferase Enzyme Complex as Revealed by Isotopic Labeling and LC-MS/MS

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