首页> 外文会议>American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics >UHPLC-MS-MS with Fast Precursor Ion and Neutral Loss Scanning and Glutathione Trapping for Detecting Reactive Metabolites of Glabridin, an Isoflavan from Licorice
【24h】

UHPLC-MS-MS with Fast Precursor Ion and Neutral Loss Scanning and Glutathione Trapping for Detecting Reactive Metabolites of Glabridin, an Isoflavan from Licorice

机译:UHPLC-MS-MS具有快速前体离子和中性损失扫描和谷胱甘肽,用于检测来自甘草的异黄酮的无反应性代谢物

获取原文

摘要

Mixtures of GSH and labeled GSH during UHPLC-MS-MS facilitated the unambiguous detection of GSH conjugates of electrophilic metabolites. Polarity switching with precursor ion and constant neutralloss MS- MS scanning permitted the detection of more GSH conjugates than before. Three GSH conjugates of glabridin were detected, and epoxide intermediates were implicated.
机译:在UHPLC-MS-MS期间GSH和标记GSH的混合物促进了亲电子代谢物的GSH缀合物的明确检测。具有前体离子的极性切换和恒定的中性校位MS-MS扫描允许检测比以前更多的GSH缀合物。检测到Glabridin的三种GSH缀合物,牵连环氧化物中间体。

著录项

相似文献

  • 外文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号