Optimizing Mass Spectrometry-based Detection of Aβ Variants and their Associated Proteins in Alzheimer's Disease Senile Plaque-Containing Tissues

机译：优化基于质谱的Aβ变体检测及其在阿尔茨海默氏病老年斑块组织中的相关蛋白质检测

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To eliminate sample loss, especially for microdissected tissues, a LC/MS-compatible approach was established using ammonium bicarbonate for binding and washing buffer for IP reaction and RapiGest as a degradable surfactant for protein extraction. Further differential extraction approaches may be adapted to increase the proteome coverage.

机译：为了消除样品损失，特别是对于微小微小组织，使用碳酸氢铵进行LC / MS相容性方法，用于为IP反应的结合和洗涤缓冲液和作为蛋白质萃取的可降解表面活性剂的Capigest。进一步的差分提取方法可以适于增加蛋白质组覆盖率。

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《American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics》|2013年||共1页
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Ko-yi Chien; Ina Caesar; Sam Gandy; Rong Wang;
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1. DETECTION AND CHARACTERIZATION OF VARIANT AND MODIFIED STRUCTURES OF PROTEINS IN BLOOD AND TISSUES BY MASS SPECTROMETRY [J] . Akira Shimizu, Toyofumi Nakanishi, Ayako Miyazaki Mass Spectrometry Reviews . 2006,第5期

机译：质谱法检测和鉴定血液和组织中蛋白质的变异结构和修饰结构。
2. Advances in the detection of prion protein in peripheral tissues of variant Creutzfeldt-Jakob disease patients using paraffin-embedded tissue blotting. [J] . Ritchie DL, Head MW, Ironside JW Neuropathology and applied neurobiology . 2004,第4期

机译：石蜡包埋的组织印迹技术在变异型克雅氏病患者外周组织中检测ion病毒蛋白的研究进展。
3. Novel mass spectrometry based detection and identification of variants of rabies virus nucleoprotein in infected brain tissues [J] . Matthew Reed, Olga Stuchlik, William C. Carson, PLOS Neglected Tropical Diseases . 2018,第12期

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4. Optimizing Mass Spectrometry-based Detection of Aβ Variants and their Associated Proteins in Alzheimer's Disease Senile Plaque-Containing Tissues [C] . Ko-yi Chien, Ina Caesar, Sam Gandy, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

机译：优化基于质谱的Aβ变体检测及其在阿尔茨海默氏病老年斑块组织中的相关蛋白质检测
5. Mass Spectrometry-based Metabolomics Delineates Biochemical Changes in 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Toxicity, High-Fructose Diet Effect, Alzheimer's Disease and Viral Infection [D] . Lin, Shuhai 2011

机译：基于质谱的代谢组学描述了2,3,7,8-四氯二苯并-p-二恶英毒性，高果糖饮食效应，阿尔茨海默氏病和病毒感染的生化变化
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7. Combined tissue and fluid proteomics with Tandem Mass Tags to identify low-abundance protein biomarkers of disease in peripheral body fluid: An Alzheimer's Disease case study [O] . Claire L. Russell, Amanda Heslegrave, Vikram Mitra, 2016

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Optimizing Mass Spectrometry-based Detection of Aβ Variants and their Associated Proteins in Alzheimer's Disease Senile Plaque-Containing Tissues

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