A new antibody raised against CD2 may be a novel marker of glial differentiation

机译：针对CD2引发的新抗体可能是胶质分化的新标记

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Distinguishing astrocytic from oligodendroglial differentiation in diffuse gliomas is a diagnostic challenge in surgical neuropathology. New markers are constantly being sought to aid in glioma classification [1]. Glial fibrillary acid protein (GFAP) is a reliable immunoperoxidase marker of astrocytic differentiation, but also stains minigemistocytes and gliofibrillary oligodendrocytes.CD2 is a T-lymphocyte cell-adhesion molecule that mediates adhesion of T cells to antigen-presenting cells [2,3]. This marker is used in the investigation of T-cell neoplasms. To date, CD2 expression has not been reported in glial or neuronal cells.A new antibody raised against CD2, code: SG-CD2 (D2) was incidentally found to stain a subset of astrocytic cells in central nervous system (CNS) neoplasms. Such a pattern of immunostaining is not seen with a commercially available monoclonal antibody against CD2 (Novocastra, UK). This study aimed to investigate the staining pattern of D2 in a variety of neurosurgical specimens. Of particular interest was whether D2 was useful in distinguishing astrocytomas from other gliomas, in particular oligodendroglioma.

机译：将星形胶质细胞与弥散性神经元分化的区分是手术神经病理学中的诊断攻击。不断寻求新的标记来帮助胶质瘤分类[1]。胶质纤维酸蛋白（GFAP）是星形胶质细胞分化的可靠免疫氧化酶标志物，但也染色致淋巴细胞细胞和胶质纤维细胞寡核细胞.CD2是介导T细胞粘附到抗原呈递细胞的T淋巴细胞细胞 - 粘附分子[2,3] 。该标记用于调查T细胞肿瘤。迄今为止，尚未在胶质或神经元细胞中报道CD2表达。依附于CD2的新抗体，代码：SG-CD2（D2）被偶切地发现中枢神经系统（CNS）肿瘤中的星形细胞子集。用抗CD2（NovoFastra，UK）的市售单克隆抗体没有看到这种免疫染色模式。本研究旨在研究各种神经外科标本中D2的染色模式。特别令人兴趣的是D2是否可用于区分星形细胞瘤，特别是寡头瘤，特别是oligodendroglioma。

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《International Congress of Neuropathology》|2010年||共6页
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Lee HY; Koh HKM; Tan SY;
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中图分类神经病理学、病因学;
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1. A population of human brain parenchymal cells express markers of glial, neuronal and early neural cells and differentiate into cells of neuronal and glial lineages. [J] . Rieske P, Azizi SA, Augelli B, The European Journal of Neuroscience . 2007,第1期

机译：人脑实质细胞群体表达神经胶质，神经元和早期神经细胞的标志物，并分化为神经元和神经胶质谱系的细胞。
2. A monoclonal antibody raised against an [Na+K+]coupled l‐glutamate transporter purified from rat brain confirms glial cell localization [J] . Danbolt Niels C., Lehre Knut P., Levy Line M., FEBS Letters . 1993,第1a2期

机译：纯化自大鼠脑的针对[Na + K +]偶联的l-谷氨酸转运蛋白的单克隆抗体证实了神经胶质细胞的定位
3. Anti-glial nuclear antibody: marker of lung cancer-related paraneoplastic neurological syndromes. [J] . Graus F, Vincent A, Pozo Rosich P, Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2005,第1a2期

机译：抗神经胶质细胞核抗体：肺癌相关的副肿瘤神经综合症的标志。
4. A new antibody raised against CD2 may be a novel marker of glial differentiation [C] . Lee HY, Koh HKM, Tan SY International Congress of Neuropathology . 2010

机译：针对CD2引发的新抗体可能是胶质分化的新标记
5. Characterization and partial purification of a plasma protein that induces rat cerebral type 2 astroglia from bipotential glial progenitors, or, Ode to a glial cell's differentiation. [D] . Levison, Steven William. 1990

机译：从双能神经胶质祖细胞或神经胶质细胞分化诱导大鼠大脑2型星形胶质细胞的血浆蛋白的表征和部分纯化。
6. A New Marker on Chicken Hematopoietic Cells isDefined by a Monoclonal Antibody Raised Against a V ßChain of the Human TCR [O] . Anne-Sophie Lacoste-Eleaume, Christian Bleux, Catherine Corbel, 1992

机译：鸡造血细胞的新标记是由针对Vß的单克隆抗体定义人类TCR链
7. A monoclonal antibody raised against an Na+K+coupled l-glutamate transporter purified from rat brain confirms glial cell localization [O] . Levy Line M., Lehre Knut P., Rolstad Bent, 1993

机译：纯化自大鼠脑的针对Na + K +偶联的l-谷氨酸转运蛋白的单克隆抗体证实神经胶质细胞定位

A new antibody raised against CD2 may be a novel marker of glial differentiation

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