Alzheimer disease (AD) is neuropathologically well defined by senile plaques and neurofibrillary tangles. We present a case of a patient with a history of progressive bulbar paralysis. Postmortem brain examination revealed extensive neuronal tau pathology affecting the most severely dorsal brainstem. We compared brainstem pathology of the patient with those of 9 demented patients with AD. Hyperphosphorylated tau (AT8), 3R and 4R tau isoforms, and beta amyloid were studied immunohistochemi-cally. Image analysis was employed to quantify AT8 immunoreactivity (IR), and both IR surface area and relative signal intensity were calculated for all cases analyzed. The results showed more than four times larger AT8 IR surface area in our patient's brainstem compared to the average AT8 IR surface area in the AD cases' brainstems. Both 3R and 4R tau immunoreactivity was detected in all brain tested. Based on our findings and the clinical presentation, our case is considered to have had probably a bulbar type of AD.
展开▼
机译：阿尔茨海默病（AD）是由老年斑块和神经纤维斑缠结的神经病理学。我们提出了一个患者患有渐进式挥发瘫痪的病史。后期脑检查显示出影响最严重的背部脑干的广泛神经元TAU病理学。我们将患者的脑干病理与AD患者的脑干病理进行了比较。免疫组织化学研究，研究了高磷酸化TAU（AT8），3R和4R TAU同种型和β淀粉样蛋白。采用图像分析来量化AT8免疫反应性（IR），并且对分析的所有病例计算IR表面区域和相对信号强度。结果在我们的患者的脑干中显示出超过4倍以上的AT8 IR表面积，而AD案例脑干中的平均AT8 IR表面积相比。在所有脑中检测到3R和4R Tau Tau P免疫反应性。根据我们的调查结果和临床演示，我们的案例被认为可能是一个挥发栏类型的广告。
展开▼
