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Improvement of CPP-RBD for siRNA Delivery

机译:SiRNA交付的CPP-RBD改进

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摘要

Small interfering RNA (siRNA) containing sequence homologous to specific gene causes sequence-specific gene silencing, which is termed RNA interference (RNAi). RNAi was first discovered in Caenorhabditis elegans, and its applicability to mammals was recently discovered. RNAi offers one of the most attractive methods for therapy of genetic diseases such as cancer and viral infections. At present, to deliver the siRNA into cells, virus vectors or polymers are used as siRNA carrier. However, these carriers are concerned about integration of viral RNA or high toxicity for cells. It is necessary to deliver siRNA into the cells safely and efficiently in order to apply the RNAi strategy for therapy.
机译:含有对特异性基因的序列的小干扰RNA(siRNA)使得序列特异性基因沉默,其被称为RNA干扰(RNAi)。 RNAi在Caenorhabditis elegiss中首次发现,最近发现了对哺乳动物的适用性。 RNAi提供了最具吸引力的方法之一,用于治疗遗传疾病,如癌症和病毒感染。目前,将siRNA递送到细胞中,病毒载体或聚合物用作siRNA载体。然而,这些载体担心纳入病毒RNA或高毒性对细胞的融合。必须安全有效地将siRNA递送到细胞中,以应用RNAI策略进行治疗。

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