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首页> 外文会议>Annual and International Meeting of the Japanese Association for Animal Cell Technology >Magnetic Force-Based Tissue Engineering of Skeletal Muscle for Bio-Actuator
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Magnetic Force-Based Tissue Engineering of Skeletal Muscle for Bio-Actuator

机译：基于磁力的生物执行器骨骼肌组织工程

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摘要

Micro-actuators have attracted considerable attention for applications in various fields such as micro-total analysis system (mu-TAS) and lab-on-a-chip. Recently, bio-actuators have been developed because biological cells may be powered without requiring external energy sources. For instance, there are some examples such as hydrogel micropillar and cardiomyocyte sheet actuator. Actuating principle of the hydrogel micropillar was powered by cultured primary neonatal rat cardiomyocytes. The fabricatedpolymer pillars were-100 mu m in length and cell adhesion peptides were immobilized on the hydrogel surface to promote attachment of cardiomyocytes to the pillars. Total natural contractile forces of single or a few cardiomyocytes attached to the pillarseemed to exceed 80 nN, as estimated from displacement of the micropillar. On the other hand, actuating principle of the cardiomyocyte sheet actuator was powered by a cultured primary neonatal rat cardiomyocyte sheet. Diaphragm and fluid in a chamber were driven by the attached cardiomyocyte sheet. Using micro-check valves, directional fluid flow was generated. The expected flow rate using ideal check valves to regulate the flow direction of the actuator without loss was estimated to be 0.24 muL/min.
机译：微型执行器引起了各种领域的应用的相当大，如微量分析系统（MU-TAS）和实验室芯片。最近，已经开发了生物致动器，因为生物电池可以被供电而不需要外部能源。例如，存在一些实施例，例如水凝胶微米和心肌细胞片致动器。水凝胶微米的致动原理由培养的原发性新生大鼠心肌细胞供电。制备合并柱为-100μm，长度和细胞粘附肽固定在水凝胶表面上，以促进心肌细胞的附着在柱上。单个或少量心肌细胞的全部天然收缩力，其附着于沉淀物以超过80nn，从MicroPillar的位移估计。另一方面，心肌细胞片致动器的致动原理由培养的原发性新生大鼠心肌细胞片供电。隔膜和腔室中的液体由附着的心肌细胞片驱动。使用微校验阀，产生定向流体流动。使用理想止回阀调节致动器的流动方向而不损失的预期流速估计为0.24 muL / min。

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