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Retroviral Vectors Pseudotyped with Chimeric Vesicular Stomatitis Virus Glycoprotein for Antibody-Dependent Gene Transduction

机译:逆转录载体与嵌合杂质口炎病毒糖蛋白拷贝型依赖于抗体依赖性基因转导

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Gene delivery technology has been essential for biotechnology since they have been used for establishing recombinant animal cell lines for the production of pharmaceutical agents, for the generation of transgenic animals, and for gene therapy. Among gene delivery procedures, retroviral vectors (including lentiviral vectors) derived from RNA viruses have been used widely when stable gene transfer is required both in vitro and in vivo, because of their ability to integrate the gene of interest into thegenome of host cells including non-dividing cells.
机译:基因递送技术对于生物技术至关重要,因为它们已被用于建立用于生产药剂的重组动物细胞系,用于产生转基因动物,以及基因治疗。在基因递送程序中,当在体外和体内需要稳定的基因转移时,已经广泛使用来自RNA病毒的逆转录病毒载体(包括慢病毒载体),因为它们能够将感兴趣的基因集成到包括非宿主细胞的宿主细胞中的基因中 - 分类细胞。

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