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首页> 外文会议>Annual and International Meeting of the Japanese Association for Animal Cell Technology >Comparison of Immunoresponses Between Cecal Patch Cells and Peyer's Patch Cells Stimulated by Bacterial Components
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Comparison of Immunoresponses Between Cecal Patch Cells and Peyer's Patch Cells Stimulated by Bacterial Components

机译：细菌组分刺激肠梗阻细胞和Peyer抗补蛋白的免疫反应器的比较

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摘要

The mucosa of the gastrointestinal tract is constantly exposed to various antigens, including commensal or pathogenic bacteria and dietary foods. In the Peyer's patches (PPs), one of the gut-associated lymphoid tissues (GALT), commensal and pathogenicbacteria are taken up into M cells via intracellular transport prior to stimulation of mucosal antigen-presenting cells (APCs). Next, APCs transmit this stimulus to T cells, thus promoting immunoresponses in the small intestine. Interestingly, commensalbacteria are able to exist in the gut without hypersensitivity, but pathogens induce remarkable immunoresponses leading to their removal by the gut immune system. On the other hand, more than 99% of intestinal commensal bacteria are localized in the large intestine in which lymphoid tissues including cecal patches (CPs) and colonic patches are located. Therefore, immune system in the large intestine is supposed to be stimulated by these various commensal bacteria, but the characteristics of the large intestinal immunoresponses to them have not been clarified.
机译：胃肠道的粘膜持续暴露于各种抗原，包括共生或病原细菌和饮食食品。在Peyer的贴剂（PPS）中，通过细胞内转运在刺激粘膜抗原呈递细胞（APC）之前，将肠道相关淋巴组织（GALT），共生和病因间的一种肠道相关淋巴组织（GALT），共生和致病杆菌中的一种。接下来，APC将该刺激传递给T细胞，从而促进小肠中的免疫信件。有趣的是，共谋间苯可在肠道中存在而没有过敏，但病原体诱导显着的免疫反对子，导致肠道免疫系统移除。另一方面，超过99％的肠道共生细菌位于大肠中，其中位于其中淋巴组织（CPS）和结肠斑块的淋巴组织。因此，在大肠中的免疫系统应该受到这些各种共生细菌的刺激，但尚未澄清对它们的大型肠免疫概念的特征。

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