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首页> 外文会议>Annual and International Meeting of the Japanese Association for Animal Cell Technology >DNA Microarray in Nutrigenomics and Cancer Prevention Research: Elucidating Molecular Signatures of Cancer Preventive Phytochemicals
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DNA Microarray in Nutrigenomics and Cancer Prevention Research: Elucidating Molecular Signatures of Cancer Preventive Phytochemicals

机译：DNA微阵列在Nutrigenomics和癌症预防研究中：阐明癌症预防植物化学的分子签名

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Population and experimental studies have implicated dietary components in the prevention of prostate cancer. In particular, consumption of a diet that is rich in fruits, vegetables, and legumes is associated with a decreased risk for prostate and other forms of cancer. Hence, there is much interest in pursuing the development of food-derived products or compounds as chemopreventive agents due to their expected safety and the fact that they are not perceived as medicine per se. However, the moleculartargets of phytochemicals, as well as the mechanisms that contribute to their beneficial effects on cancer, remain elusive. Further elucidation of the molecular targets, i.e. molecular signatures and mechanisms, would be important in understanding theircancer preventive properties. In our pursuit of these important and complex issues, we have taken two approaches to address these questions. One approach described in this report examined the effects of phytochemicals on specific pathways such as apoptosis; the other used DNA microarray analysis as a global gene expression profiling tool. Our work on resveratrol, a grape derived candidate cancer protective agent, is highlighted. Resveratrol is a polyphenol (3, 4, 5 -trihydroxystilbene) categorized as aphytoalexin found principally in the skin of grapes, peanuts, and other plant species. Recent studies attributed a variety of health benefits to consumption of foods containing resveratrol, including protection against cancers, cardiovascular disease, and aging. However, despite works suggesting that resveratrol showed promise as a prostate cancer chemopreventive agent, the in vivo effects of resveratrol, as well as the mechanisms underlying those effects on prostate cancer, remain largely unknown.
机译：人口和实验研究涉及预防前列腺癌的膳食成分。特别是，富含水果，蔬菜和豆类的饮食的消耗与前列腺和其他形式的癌症的风险降低有关。因此，由于其预期的安全性，追求食品衍生产品或化合物作为化学预防性剂的发展有很多兴趣的兴趣和它们未被视为本身的药物。然而，植物化学的分子，以及有助于他们对癌症的有益作用的机制仍然难以捉摸。进一步阐明分子靶标，即分子签名和机制，在理解其癌症预防性质方面是重要的。在我们对这些重要和复杂的问题的追求中，我们采取了两种方法来解决这些问题。本报告中描述的一种方法检测了植物化学物质对细胞凋亡等特异性途径的影响;另一个使用的DNA微阵列分析作为全局基因表达分析工具。我们对白藜芦醇的工作，突出了葡萄衍生的候选癌症保护剂。白藜芦醇是一种多酚（3,4,5-三羟基苯乙烯），分类为主要在葡萄，花生和其他植物物种的皮肤中发现。最近的研究将各种健康益处归因于含有白藜芦醇的食物消费，包括防止癌症，心血管疾病和老化。然而，尽管有效地表明白藜芦醇作为前列腺癌化学预防剂的承诺，白藜芦醇的体内效应以及依赖于前列腺癌的影响的机制仍然很大程度上。

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