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首页> 外文会议>Annual and International Meeting of the Japanese Association for Animal Cell Technology >Molecular Cloning and Characterization of a Novel Canine Sulfotransferase
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Molecular Cloning and Characterization of a Novel Canine Sulfotransferase

机译：新型犬磺旋转转移酶的分子克隆与表征

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摘要

The cytosolic sulfotransferases (SULTs) are enzymes that catalyze the transfer of a sulfonate group from the active sulfate, 3'-phosphoadenosine 5'-phosphosulfate (PAPS), to a hydroxyl or an amino group of an acceptor compound. Sulfonation representsan important mechanism in vivo for the metabolism/detoxification of the drugs and other xenobiotics, as well as endogenous compounds such as steroids and thyroid hormones, catecholamine neurotransmitters, and bile acids in mammals. It has been proposed that all cytosolic SULTs constitute a gene superfamily, within which several SULT gene families have been classified. It is generally accepted that members of the same SULT gene family share at least 45% amino acid sequence identity, while members of a subfamilies further divided within each SULT gene family are greater than 60% identical in amino acid sequence, Presently, there are six SULT gene families: SULT1 (phenol sulfotransferases), SULT2 (hydroxysteroid sulfotransferases), SULT3 (amine sulfotransferases), SULT4, SULT5, and SULT6. Tissue/organ-specific distribution and ontogenetic expression of some cytosolic SULTs have been studied in human, mouse, and rat, and the results showed that different SULTs may differ in tissue/organ and developmentalstage distribution.
机译：胞质磺基转移酶（SULTS）是催化磺酸盐基团从活性硫酸盐，3'-磷甲酸甜5'-磷酸盐（PAPS）的转移至受体化合物的羟基或氨基的酶。磺化是体内代谢的重要机制，用于药物和其他异种症的代谢/解毒，以及内源化合物，如类固醇和甲状腺激素，儿茶酚胺神经递质和哺乳动物的胆汁酸。已经提出，所有细胞溶质的疾病都构成了一个基因超家族，其中几个苏尔基因家族被分类。普遍认为，同一苏格林基因家族的成员共有至少45％的氨基酸序列同一性，而亚属的成员进一步划分在每个SULT基因家族内部在氨基酸序列中相同的60％，则存在六个SULT基因家族：SULT1（苯酚磺基转移酶），SULT2（羟类磺基转移酶），SULT3（胺磺当样），SULT4，SULT5和SULT6。在人，小鼠和大鼠中已经研究了组织/器官特异性分布和某些细胞溶质美食的髓鞘表达，结果表明，组织/器官和发育术分布的不同可能不同。

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