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Effect of GSH depletion, hyperthermia, and pulsed magnetic fields on an Hsp7O/Luc reporter system

机译:GSH耗尽,高温和脉冲磁场对HSP7O / LUC报道系统的影响

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Heat shock proteins, particularly Hsp70, are produced in response to a number of cellular stresses. The most well known example is exposure to heat, but conditions of oxidative stress have also been shown to induce HSP70 [1; 2; 3] . GSH is one of the most important low molecular weight antioxidants in the cell. Depletion of GSH is known to increase the amount of reactive oxygen species-(ROS) in a cell thus exposing the cell to oxidative stress [4]. A number of groups have found that-modulating the concentration of GSH in the cell alters the Hsp70 protein levels [5; 6; 7; 8].
机译:响应于多种细胞应力,产生热休克蛋白,特别是HSP70。最着名的例子是暴露于热量,但也显示出氧化应激的条件诱导Hsp70 [1; 2; 3]。 GSH是细胞中最重要的低分子量抗氧化剂之一。已知GSH的耗竭,以增加电池中的活性氧物质 - (ROS)的量,从而将电池暴露于氧化应激[4]。许多组发现 - 调节细胞中GSH的浓度改变了HSP70蛋白水平[5; 6; 7; 8]。

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