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首页> 外文会议>Meeting of the Bioelectromagnetics Society >Nanosecond Pulsed Electric Field Therapy that Causes Skin Tumors to Self-Destruct with a Single Treatment
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Nanosecond Pulsed Electric Field Therapy that Causes Skin Tumors to Self-Destruct with a Single Treatment

机译：纳秒脉冲电场疗法导致皮肤肿瘤与单一治疗的自毁

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We have previously reported that nanosecond pulsed electric fields (nsPEF) can eliminate murine skin tumorshs. These studies used parallel plate electrodes that were incompatible with human skin and required multiple treatments. Here we introduce pew suction electrodes compatible with human skin andhave identified nsPEF therapy parameters that can eliminate murine melanomas and basal cell carcinomas with a single treatment. These pulses initiate apoptosis in the tumor cells without hyperthermia. We have used both a xenograft nude mouse melanoma model system and endogenous tumors in transgenic mice. We identified the minimal field strength, pulse frequency and pulse number for this therapy. When We used these optimal pulse parameters of 2000 pulses, 100 ns in duration, and 30 kV/cm in. amplitude at a pulse frequency of 5-7 pulses/s, we eliminated all 17 melanomas treated in 4 mice. This was the highest pulse frequency that we could use without raising the skin tumor. temperature above 40 °C. We also demonstrate that the effects of nsPEF therapy are highly localized to only those cells located within the suction electrode and results in' very little scarring of the nsPEF-treated skin.
机译：我们之前报道纳秒脉冲电场（NPEF）可以消除小鼠皮肤肿瘤。这些研究使用与人体皮肤不相容的平行板电极并需要多种处理。在这里，我们介绍与人体皮肤相容的PEW吸附电极，并且鉴定的NSPEF治疗参数可以通过单一治疗消除鼠黑色素和基底细胞癌。这些脉冲在没有热疗的情况下引发肿瘤细胞中的细胞凋亡。我们在转基因小鼠中使用了异种移植裸鼠裸鼠黑素瘤模型系统和内源性肿瘤。我们确定了这种治疗的最小场强，脉冲频率和脉冲数。当我们使用2000脉冲的这些最佳脉冲参数时，持续时间为100ns，脉冲频率为5-7脉冲/ s的脉冲频率，我们消除了4只小鼠的所有17个黑色素瘤。这是我们可以使用的最高脉冲频率，而无需提高皮肤肿瘤。温度高于40°C。我们还证明NPEF治疗的影响仅对位于吸入电极内的那些细胞高度本地化，并导致'NPSPEF处理的皮肤的瘢痕出来。

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