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首页> 外文会议>National Fluid Mechanics and Fluid Power Conference >ANALYSIS OF BLAST INDUCED INTRACRANIAL PRESSURE DYNAMICS IN CEREBROSPINAL FLUID LEADING TO TRAUMATIC BRAIN INJURY
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ANALYSIS OF BLAST INDUCED INTRACRANIAL PRESSURE DYNAMICS IN CEREBROSPINAL FLUID LEADING TO TRAUMATIC BRAIN INJURY

机译：脑脊液中颅内颅内压力的分析导致创伤性脑损伤

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A medical paradox was encountered by neurologists while treating soldiers who had survived explosions in warfronts. There were evidences of memory deficits, speech problems and difficulties with decision-making in these patients. The significant observation was that most of these patients had not suffered a direct head injury. Nevertheless scan reports suggested enlargement of brain ventricles with minor bleeding. Such conditions were termed as Blast Induced Traumatic Brain Injury (TBI). Certain studies show the development of stresses in various parts of the brain due to explosions; none of them directly correlating the expansion of Cerebrospinal fluid (CSF) pathways and brain ventricles, which is believed to be the indication of TBI. This work primarily explores the role of intracranial CSF pressure dynamics in the genesis of TBI; emphasis being on the evolution of the unsteady pressure field within CSF pathways, ventricular and the subarchnoid region with the brain parenchyma. The continuity and Navier-Stokes equations are solved for the CSF flow under the influence of blast. It has been observed that an unsteady pressure response is developed in the CSF pathways. The pressure gradient between the ventricles and the porous parenchyma is considerably high which is indicative of the ventricular expansion. This intense activity of varying pressure gradient occurs within few milliseconds of the blast application. Our work qualitatively evaluates the CSF pressure instabilities at various instants of time that may be related to the cause of expansion of CSF pathways and ventricular spaces.
机译：神经科医生遇到了一种医疗悖论，同时处理在沃思堡爆炸中幸存下来的士兵。在这些患者中有记忆缺陷，言语问题和困难的证据。显着观察是，大多数这些患者没有遭受直接头部损伤。然而，扫描报告表明脑室扩大了轻微的出血。这些病症被称为Blast诱导的创伤性脑损伤（TBI）。某些研究表明，由于爆炸，大脑的各个部位的应力的发展;它们都不是直接关联脑脊髓液（CSF）途径和脑室的扩张，这被认为是TBI的指示。这项工作主要探讨了颅内CSF压力动力学在TBI的成因中的作用;强调CSF途径，心室和大脑实质脑膜炎地区的不稳定压力场的演变。在爆炸的影响下解决了CSF流的连续性和Navier-Stokes方程。已经观察到在CSF途径中开发了不稳定的压力响应。心室和多孔薄壁症之间的压力梯度显着高，这表明心室膨胀。这种不同的压力梯度的激烈活动发生在爆炸应用的几毫秒内。我们的工作在定性地评估了在可能与CSF途径和心室空间的扩张原因相关的各个时间内的CSF压力稳定性。

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