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Comparison of Aggregational Behavior of Amyloid β-peptide (1-42) and (1-40) on Cell Membranes

机译：淀粉样蛋白β-肽（1-42）和（1-40）对细胞膜的聚集行为的比较

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We examined the aggregational behavior of Aβ-(1-42) and (1-40) on cell membranes by monitoring their accumulation on living human neuroblastoma SH-SY5Y cells and the concurrent cell death. Similar results were obtained with Aβ-(1-42) and Aβ-(1-40); however, a 10-fold higher concentration was required for the latter. Cell death was observed only after substantial amounts of fibrils had accumulated on cell membranes, suggesting that fibril-induced disruption of cell membranes leads to cell death.

机译：通过监测活性人神经母细胞瘤SH-SY5Y细胞和并发细胞死亡，通过监测它们的积累和同时性细胞死亡，检查了Aβ-（1-42）和（1-40）的聚集行为和（1-40）对细胞膜的聚集行为。用Aβ-（1-42）和Aβ-（1-40）获得类似的结果;然而，后者需要10倍的浓度。仅在累积在细胞膜积累的大量原纤维中仅观察到细胞死亡，表明Fibril引起的细胞膜破坏导致细胞死亡。

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《Japanese peptide symposium》|2010年||共2页
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Mariko Ogawa; Takahiro Yamaguchi; Yoshiaki Yano;
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中图分类肽类;
关键词
amyloid β-peptides; cell membranes; confocal laser scanning microscopy; fibril formation; total internal reflection microscopy;

机译：淀粉样蛋白β-肽;细胞膜;共聚焦激光扫描显微镜;原纤维形成;全内反射显微镜;

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专利

1. Capillary electrophoresis studies on the aggregation process of beta-amyloid 1-42 and 1-40 peptides. [J] . Sabella S, Lanni C, Govoni S, Electrophoresis: The Official Journal of the International Electrophoresis Society . 2004,第18a19期

机译：毛细管电泳研究β-淀粉样蛋白1-42和1-40肽的聚集过程。
2. Ganglioside-mediated aggregation of amyloid beta-proteins (Abeta): comparison between Abeta-(1-42) and Abeta-(1-40). [J] . Ogawa M, Tsukuda M, Yamaguchi T, Journal of Neurochemistry: Offical Journal of the International Society for Neurochemistry . 2011,第5期

机译：神经节苷脂介导的淀粉样β蛋白（Abeta）的聚集：Abeta-（1-42）和Abeta-（1-40）之间的比较。
3. Direct Observations of Amyloid b Self-Assembly in Live Cells Provide Insights into Differences in the Kinetics of Ab(1-40) and Ab(1-42) Aggregation [J] . Elin K. Esbj?rner, Fiona Chan, Eric Rees, Chemistry & biology . 2014,第6期

机译：在活细胞中对淀粉样蛋白b自组装的直接观察提供了洞察Ab（1-40）和Ab（1-42）聚集动力学的差异
4. Comparison of Aggregational Behavior of Amyloid β-peptide (1-42) and (1-40) on Cell Membranes [C] . Mariko Ogawa, Takahiro Yamaguchi, Yoshiaki Yano Japanese peptide symposium . 2010

机译：淀粉样蛋白β-肽（1-42）和（1-40）对细胞膜的聚集行为的比较
5. Single molecule studies of beta-amyloid(1-40) peptide in Alzheimer's disease. [D] . Ding, Hao. 2009

机译：β-淀粉样蛋白（1-40）肽在阿尔茨海默氏病中的单分子研究。
6. Comparing the Aggregation Free Energy Landscapes of Amyloid Beta(1-42) and Amyloid Beta(1-40) [O] . Weihua Zheng, Min-Yeh Tsai, Peter G. Wolynes -1

机译：比较淀粉样β（1-42）和淀粉样β（1-40）的聚集自由能态
7. Ganglioside-mediated aggregation of amyloid β-proteins (Aβ): comparison between Aβ-(1-42) and Aβ-(1-40) [O] . Mariko Ogawa, Miho Tsukuda, Takahiro Yamaguchi, 2011

机译：神经节苷脂介导的淀粉样蛋白β-蛋白（Aβ）的聚集：Aβ-（1-42）和Aβ-（1-40）之间的比较

Comparison of Aggregational Behavior of Amyloid β-peptide (1-42) and (1-40) on Cell Membranes

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