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Low Threshold of Destabilization for Loss of Tumor Suppressor Activity of p53: A Quantitative Analysis of p53 Tetramerization Domain Mutants

机译：P53肿瘤抑制剂损失损失低阈值的稳定性：P53四聚化结构域突变体的定量分析

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Tetramer formation of tumor suppressor protein p53 is essential for its activity. Our comprehensive and quantitative analyses of the oligomeric stability of p53 tumor-derived mutants revealed that the threshold of stability in the p53 tetrameric structure for loss of tumor suppressor activity could be very low.

机译：肿瘤抑制蛋白P53的四聚体形成对于其活性至关重要。我们对P53肿瘤衍生突变体的寡聚稳定性的综合和定量分析显示，P53四聚体损失损失的稳定性阈值可能非常低。

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《Japanese peptide symposium》|2011年||共1页
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作者
Rui Kamada; Takao Nomura; Yoshiro Chuman;
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中图分类肽类;
关键词
p53 cancer mutations; protein stability; protein oligomerization; thermal denaturation; transcription factor;

机译：p53癌症突变;蛋白质稳定性;蛋白质寡聚化;热变性;转录因子;

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专利

1. Δ122p53, a mouse model of Δ133p53α, enhances the tumor-suppressor activities of an attenuated p53 mutant [J] . T L Slatter, N Hung, S Bowie, Cell death & disease. . 2015,第6期

机译：Δ122p53是Δ133p53α的小鼠模型，可增强减毒p53突变体的肿瘤抑制活性
2. 702 Quantitative analysis of p53-targeted gene expression and visualization of p53 transcriptional activity following intratumoral administration of adenoviral p53 in vivo [J] . S.Ohtani, S.Kagawa, T.Fujiwara, European Journal of Cancer Supplements . 2003,第5期

机译：702体内瘤内给予腺病毒p53后p53靶向基因表达的定量分析和p53转录活性的可视化
3. Inhibition of tumor suppressor protein p53-dependent transcription by a tetramerization domain peptide via hetero-oligomerization [J] . WadaJ., KamadaR., ImagawaT., Bioorganic and Medicinal Chemistry Letters . 2012,第8期

机译：通过杂寡聚化的四聚化结构域肽抑制肿瘤抑制蛋白P53依赖性转录
4. Low Threshold of Destabilization for Loss of Tumor Suppressor Activity of p53: A Quantitative Analysis of p53 Tetramerization Domain Mutants [C] . Rui Kamada, Takao Nomura, Yoshiro Chuman Japanese peptide symposium . 2011

机译：P53肿瘤抑制剂损失损失低阈值的稳定性：P53四聚化结构域突变体的定量分析
5. p53 transactivation domain mutant knock-in mice provide novel insight into p53 tumor suppressor function. [D] . Johnson, Thomas M. 2007

机译：p53反式激活域突变敲除小鼠提供p53肿瘤抑制功能的新见解。
6. Δ122p53 a mouse model of Δ133p53α enhances the tumor-suppressor activities of an attenuated p53 mutant [O] . T L Slatter, N Hung, S Bowie, 2015

机译：Δ122p53Δ133p53α的小鼠模型可增强减毒p53突变体的肿瘤抑制活性
7. Cancer-associated p53 Tetramerization Domain Mutants: QUANTITATIVE ANALYSIS REVEALS A LOW THRESHOLD FOR TUMOR SUPPRESSOR INACTIVATION* [O] . Kamada, Rui, Nomura, Takao, Anderson, Carl W., 2010

机译：癌症相关的p53四聚体结构域突变体：定量分析显示低水平的肿瘤抑制因子失活阈值*

Low Threshold of Destabilization for Loss of Tumor Suppressor Activity of p53: A Quantitative Analysis of p53 Tetramerization Domain Mutants

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