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Optimal modulation frequencies for small-tissue imaging based on theequation of radiative transfer

机译:基于辐射转移方程的小组织成像优化调制频率

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The frequency-domain experimental data is typically corrupted by noise and the measurement accuracy is compromised. Assuming the widely used shot-noise model, it is well-known that the signal-to-noise ratio (SNR) of the amplitude signal decreases with increasing frequency, whereas the SNR of phase measurement reaches a peak value in the range between 400 MHz and 800 MHz in tissue volumes typical for small animal imaging studies. As a consequence, it can be assumed that there exists an optimal frequency for which the reconstruction accuracy would be best. To determine optimal frequencies for FDOT, we investigate here the frequency dependence of optical tomographic reconstruction results using the frequency-domain equation of radiative transfer. We present numerical and experimental studies with a focus on small tissue geometries as encountered in small animal imaging and imaging of human finger joints affected by arthritis. Best results were achieved in the 400-800 MHz frequency range, depending on the particular optical properties.
机译:频率域实验数据通常通过噪声损坏,并且损害测量精度。假设广泛使用的射击噪声模型,众所周知,幅度信号的信噪比(SNR)随着频率的增加而降低,而相位测量的SNR达到400 MHz之间的峰值。小动物成像研究典型组织体积和800 MHz。因此,可以假设存在重建精度最佳的最佳频率。为了确定FDOT的最佳频率,我们在这里调查光学断层重建结果的频率依赖性,使用辐射传输的频域方程。我们在小型动物成像和受关节炎影响的人体手指关节成像中展示了数值和实验研究,重点是小型组织几何形状。在400-800MHz的频率范围内实现了最佳结果,具体取决于特定的光学性质。

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