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首页> 外文会议>SPIE Conference on Optical Tomography and Spectroscopy of Tissue >Angular domain optical projection tomography in turbid media
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Angular domain optical projection tomography in turbid media

机译：混浊介质中的角域光投影断层扫描

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Most high-resolution optical tomography techniques employ coherence domain or time domain methodologies to capture non-scattered photons in turbid media. Angular Domain Optical Projection Tomography (ADOPT) uses an angular filter array (AFA) to observe photons that propagate through a specimen with small angular deviation. We constructed an ADOPT system consisting of an AFA micro-machined silicon micro-tunnel array with each micro-tunnel 60 gm wide, 60 gm high, 10 mm long, and separated by 5 gm thick walls. The range of acceptance angles was 0° to 0.5°. The system also included an 808 nm CW diode laser, beam shaping optics, a sample cuvette, a Keplerian lens system, and a CMOS camera. Testing was performed with a target consisting of two graphite rods (0.9 mm diameter) suspended in the cuvette by a rotation stage. The target was placed in a manner that the line of laser light was perpendicular to the long axis of the rods. A multitude of projections were collected at increments of 1.8° and compiled into a sinogram. A transverse image was reconstructed from the sinogram using filtered backprojection. The sub-millimeter targets embedded in the 2 cm thick scattering medium (reduced scattering coefficient < 2.4 cm~(-1))were discernable in both the sinograms and the reconstructed images. The results suggest that ADOPT may be a useful technique for tomographic imaging of thick biological specimens (i.e. up to 8 mm across).
机译：大多数高分辨率光学断层扫描技术采用相干域或时域方法来捕获浑浊介质中的非散射光子。角域光学投影断层扫描（采用）使用角滤波器阵列（AFA）观察通过具有小角度偏差的样本传播的光子。我们建造了一种采用系统，包括AFA微机加工硅微隧道阵列，每个微型隧道60宽，60克，长10毫米，长5克厚墙。接收角的范围为0°至0.5°。该系统还包括808nm CW二极管激光器，光束整形光学器件，样品比色杯，键盘透镜系统和CMOS相机。用旋转级悬挂在比色皿中的两个石墨杆（0.9mm直径）组成的靶进行测试。以激光线垂直于杆的长轴垂直的方式放置目标。以1.8°的增量收集多个突起并编制到一个铭记图中。使用过滤的反光从Sinogram重建横向图像。嵌入在2cm厚散射介质中的亚毫米靶（减小散射系数<2.4cm〜（-1））在译文和重建的图像中可辨别。结果表明，采用可能是厚生物标本的断层摄影成像的有用技术（即，高达8毫米）。

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