Here, we reported about long-term survival gastric cancer cases with liver metastasis. Six cases with synchronous liver metastasis had been alive for more than 2 years commencing the therapy. Five cases were HI or H2 and had no non-curative factors except liver metastasis. Three cases underwent hepatectomy, and another 3 cases were treated effec-lively by anticancer drug. On effectively treated cases by an anticancer drug, first case was H2 case effectively treated by intra-hepatic arterial infusion of CDDP, 5'-DFUR and PSK. Second case was H2 case effectively treated by intra-hepatic arterial infusion of CDDP, TS-1 and PSK. Third case was in-operable because of H, N and M(adrenal gland) factor, and was treated by TS-1 and CPT-11. Two cases with metachronous liver metastasis are alive without recurrence for more than 2 years after hepatectomy, and especially, one case is still alive for 15 years after hepatectomy. These results suggested that hepatectomy was useful for HI or H2 case without non-curative factor except liver metastasis, and CPT-11 or intra-hepatic arterial infusion of CDDP with TS-1 was an effective therapy for gastric cancer with liver metastasis. On the metachronous liver metastasis, if the patient whose recurrence site in the liver was single, and had no other recurrence site, hepatecomy had to be considered, aggressively.
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