Thymidylate synthetase (TS) and dihydropyrimidine dehydrogenase(DPD)in cancer are considered to be usefull enzymes in predicting tumor sensitivity to 5-fluorourasil (5-FU). Subjects consisted of 20 patients. TS and DPD levels in the primary tumor foci were determined. The mean TS level in tissue specimens obtained from the primary tumor foci was 4.1 pmol/g tissue. The mean DPD activity in the primary tumor foci was 4L 3 pmol/min/mg protein. These analysis revealed that TS concentration correlated with tumor size(p=0.024). The mean DPD level in the patients with peritoneal dissemination was significantly higher than that in the patients without peritoneal dissemination (p=0.043). It was suggested that the determination of TS and DPD levels in tissue specimens obtained from patients with progressive gastric cancer may aid in predicting the therapeutic effects of treatment with 5-FU.
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