AGGREGATION AND LONG-TERM POSITIONING OF CELLS BY ULTRASOUND IN A MULTI-WELL MICROCHIP FOR HIGH-RESOLUTION IMAGING OF THE NATURAL KILLER CELL IMMUNE SYNAPSE

机译：通过超声在多孔微芯片中进行细胞的聚集和长期定位，用于自然杀伤细胞免疫突触的高分辨率成像

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In this study we investigate the ability of Natural Killer (NK) cells to form ultrasound-mediated intercellular contacts with target cells in a multi-well microdevice by high-resolution confocal-microscopy imaging of inhibitory immune synapses. Furthermore, we compare the NK-Target cell cluster migration with and without ultrasound actuation. Experiments indicate that clusters of cells are positioned and maintained centered in the wells for 17 hours when they are exposed continuously to ultrasound. Our system can be used for both screening high numbers of events in low resolution and also for high resolution imaging of long term cell-cell-interactions.

机译：在这项研究中，我们通过抑制免疫突触的高分辨率共聚焦 - 显微镜成像，研究了自然杀伤（NK）细胞与多孔微小的靶细胞形成超声介导的细胞间触点的能力。此外，我们将NK-Target Cell群集迁移与无超声致动进行比较。实验表明，当连续地暴露于超声时，将细胞簇定位和维持在孔中以17小时为中心。我们的系统可用于筛选低分辨率的高位事件，也可以用于长期细胞 - 细胞相互作用的高分辨率成像。

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《International Conference on Miniaturized Systems for Chemistry and Life Sciences》|2011年||共3页
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作者
A.E. Christakou; M. Ohlin; M.A. Khorshidi; T. Frisk; B. Vanherberghen; B. ?nfelt; M. Wiklund;
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中图分类 O6-532;
关键词
Natural killer cells; Immune synapse; Ultrasound; Multi-well; Microchip;

机译：天然杀手细胞;免疫突触;超声;多井;微芯片;

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专利

1. Live cell linear dichroism imaging reveals extensive membrane ruffling within the docking structure of natural killer cell immune synapses. [J] . Benninger RK, Vanherberghen B, Young S, Biophysical Journal . 2009,第2期

机译：活细胞线性二色性成像显示自然杀伤细胞免疫突触的对接结构内广泛的膜波纹。
2. Impaired dendritic cell functions because of depletion of natural killer cells disrupt antigen-specific immune responses in mice: restoration of adaptive immunity in natural killer-depleted mice by antigen-pulsed dendritic cell. [J] . Yoshida O, Akbar F, Miyake T, Clinical and Experimental Immunology: An Official Journal of the British Society for Immunology . 2008,第1期

机译：由于自然杀伤细胞的耗尽而导致树突状细胞功能受损，从而破坏了小鼠的抗原特异性免疫反应：通过抗原脉冲树突细胞恢复了自然杀伤力较弱的小鼠中的适应性免疫力。
3. Intercellular Transfer and Supramolecular Organization of Human Leukocyte Antigen C at Inhibitory Natural Killer Cell Immune Synapses [J] . Leo M. Carlin, Konstantina Eleme, Fiona E. McCann, The Journal of Experomental Medicine . 2001,第10期

机译：人白细胞抗原C在抑制性自然杀伤细胞免疫突触的细胞间转移和超分子组织。
4. AGGREGATION AND LONG-TERM POSITIONING OF CELLS BY ULTRASOUND IN A MULTI-WELL MICROCHIP FOR HIGH-RESOLUTION IMAGING OF THE NATURAL KILLER CELL IMMUNE SYNAPSE [C] . A.E. Christakou, M. Ohlin, M.A. Khorshidi, International Conference on Miniaturized Systems for Chemistry and Life Sciences . 2011

机译：通过超声在多孔微芯片中进行细胞的聚集和长期定位，用于自然杀伤细胞免疫突触的高分辨率成像
5. Innate Immunity in Interleukin-33-Mediated Tumor Suppression: Competing Roles of Natural Killer Cells and Type 2 Innate Lymphoid Cells [D] . Long, Alan Wyndham. 2019

机译：白细胞介素33介导的肿瘤抑制的先天免疫：自然杀伤细胞和2型先天淋巴细胞的竞争作用。
6. Live Cell Linear Dichroism Imaging Reveals Extensive Membrane Ruffling within the Docking Structure of Natural Killer Cell Immune Synapses [O] . Richard K.P. Benninger, Bruno Vanherberghen, Stephen Young, 2009

机译：活细胞线性二色性成像揭示了天然杀伤细胞免疫突触的对接结构内广泛的膜起皱。
7. Live Cell Linear Dichroism Imaging Reveals Extensive Membrane Ruffling within the Docking Structure of Natural Killer Cell Immune Synapses [O] . Benninger, Richard K.P., Vanherberghen, Bruno, Young, Stephen, 2009

机译：活细胞线性二色性成像揭示了天然杀伤细胞免疫突触的对接结构内广泛的膜起皱。

AGGREGATION AND LONG-TERM POSITIONING OF CELLS BY ULTRASOUND IN A MULTI-WELL MICROCHIP FOR HIGH-RESOLUTION IMAGING OF THE NATURAL KILLER CELL IMMUNE SYNAPSE

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