首页> 外文会议>Annual International Vicenza Course on Hemodialysis >CD14+CD16+ Monocftes from Chronic Kidney Disease Patients Exhibit Increased Adhesion Ability to Endothelial Cells
【24h】

CD14+CD16+ Monocftes from Chronic Kidney Disease Patients Exhibit Increased Adhesion Ability to Endothelial Cells

机译:来自慢性肾病患者的CD14 + CD16 +单酯表现出对内皮细胞的粘附能力增加

获取原文

摘要

Chronic kidney disease (CKD) patients present an inflammatory process that induces endothelial damage and therefore plays a role in the high rates of cardiovascular morbidity and mortality reported in these patients. Although new therapies have reduced the elevated serum levels of inflammatory mediators such as cytokines and CRP in CKD patients, the rise in the level of activated immu-nocompetent cells is maintained in peripheral blood, which appears to play a prominent role in the endothelial damage suffered by these patients. CD14+CD16+ monocytes are a subset of activated monocytes that are found in greater numbers in the peripheral blood of CKD patients. The increased presence of these cells is related to the endothelial damage suffered by these patients. However, the mechanism through which these cells damage the vascular endothelium is still unclear. One of the characteristics that differentiate CD14+CD16+ monocytes is their powerful ability to produce inflammatory cytokines, which may be responsible for causing damage to endothelial cells. However, it is difficult to imagine that the cytokines produced by a relatively small proportion of these cells are capable of damaging the endothelium.
机译:慢性肾脏病(CKD)患者出现炎症过程诱导内皮损伤,因此起着这些患者心血管疾病报告发病率和死亡率高利率的作用。虽然新的疗法具有减少的炎症介质如在CKD患者的细胞因子和CRP的升高的血清水平,在水平的上升激活IMMU-nocompetent细胞被维持在外周血,这出现在所遭受的内皮损伤中发挥突出的作用这些病人。 CD14 + CD16 +单核细胞是活化的单核的一个子集被在更大的数字发现慢性肾脏病患者的外周血中。这些细胞的增加的存在与由这些患者遭受的内皮损伤。然而,通过这些细胞损伤血管内皮的机制目前还不清楚。一个的特征,区分CD14 + CD16 +单核细胞是其强大以产生炎性细胞因子,其可以是负责造成损害的内皮细胞的能力。然而,很难想象由这些细胞的相对较小的比例产生的细胞因子是能够损坏内皮的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号