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首页> 外文会议>International Carbohydrate Symposium >HIGH-YIELD ENZYMATIC SYNTHESIS OF Gal β-(1->3) GalNAc and Gal β-(1->3) GlcNAc USING RECOMBINANT β-GALACTOSIDASE FROM Bacillus Circulans
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HIGH-YIELD ENZYMATIC SYNTHESIS OF Gal β-(1->3) GalNAc and Gal β-(1->3) GlcNAc USING RECOMBINANT β-GALACTOSIDASE FROM Bacillus Circulans

机译：高产酶合成Galβ-（1-> 3）Galnac和Galβ-（1-> 3）GlcNAc使用来自芽孢杆菌的重组β-半乳糖苷酶

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摘要

Oligosaccharides present on the cell surface are involved in many biological processes. Specifically, β(1->3) linked galactosides such as Galβ1-3GalNAc and Galβ1-3GlcNAc are key carbohydrate structures involved in many biological processes. There is consequently much interest in the chemical or enzymatic synthesis of these galacto-glycosides. For that reason, related oligosaccharides containing this linkage have been synthesized by chemical and enzymatic approaches. From a practical viewpoint, the use of β-galactosidases is attractive for oligosaccharide synthesis offering great control over chemo-, regio- and stereoselectivity, but resulting in low yields. At the same time there is much interest in the use of green solvents as (co)solvents to create novel reaction media for such biocatalytic processes. However, the use of glycosidases in bio-solvents is still limited and a few studies about their use in transglycosylation reactions are available.
机译：存在于细胞表面上的寡糖涉及许多生物过程。具体地，β（1-> 3）连接的半乳​​糖醇类如Galβ1-3Galnac和Galβ1-3GlCNAc是许多生物过程中涉及的关键碳水化合物结构。因此，对这些吡酰基糖苷的化学或酶促合成有很多兴趣。因此，通过化学和酶法合成了含有这种连杆的相关寡糖。从实际的观点来看，使用β-半乳糖苷酶对寡糖合成具有吸引力，可对化学，序列和立体选择性的极大控制，但导致产量低。同时，对使用绿色溶剂作为（CO）溶剂以产生新的反应介质进行这种生物催化过程。然而，在生物溶剂中使用糖苷酶仍然有限，可获得关于它们在跨糖基化反应中使用的一些研究。

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