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首页> 外文会议>International Carbohydrate Symposium >PREPARATION OF SUGAR 1-PHOAPHATES BY ANOMERIC KINASES COMBINED WITH THE ATP-REGENERATION SYSTEM USING PYRUVATE AS THE ENERGY SOURCE
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PREPARATION OF SUGAR 1-PHOAPHATES BY ANOMERIC KINASES COMBINED WITH THE ATP-REGENERATION SYSTEM USING PYRUVATE AS THE ENERGY SOURCE

机译：通过使用丙酮酸作为能量源的ATP再生系统将糖1-糖的制备与ATP再生系统合并

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摘要

Sugar 1-phosphates are important compounds in the sugar metabolism and the sugar chain-synthesis. They are also used in the enzymatic preparation of oligosaccharides by phosphorylases. Several sugar 1-phosphates can be synthesized from monosaccharides and ATP by anomeric kinases. Anomeric kinases are often inhibited severely by high concentration of ATP, their phosphate donor, making it impossible to synthesize the compounds at practical concentrations from monosaccharides and ATP. We previously demonstrated the gram-scale preparation of sugar 1-phosphates from monosaccharides and phosphoenolpyruvate (PEP) by the combined actions of anomeric kinase and pyruvate kinase [1]. The ATP-regeneration system allows the syntheses at the practical concentrations. However, this reaction consumes equimolar of PEP, an expensive compound, with the generation of sugar 1-phosphate.
机译：糖1-磷酸盐是糖代谢和糖链合成中的重要化合物。它们也用于通过磷酸化酶的寡糖制备。可以通过异常激酶从单糖和ATP合成几种糖1-磷酸酯。通过高浓度的ATP，它们的磷酸盐供体通常严重抑制异组激酶，使得不可能以单糖和ATP的实际浓度合成化合物。我们以前证明了通过异常激酶和丙酮酸激酶的组合作用[1]的组合作用，从单糖和磷酸丙酸盐（PEP）中培养了糖1-磷酸盐的革兰垢制剂[1]。 ATP再生系统允许在实际浓度下合成。然而，这种反应消耗了Equimolar的PEP，一种昂贵的化合物，产生糖1-磷酸盐。

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