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首页> 外文会议>International Carbohydrate Symposium >COMPARISON OF CAPSULAR POLYSACCHARIDE CONFORMATIONS IN STREPTOCOCCUS AGALACTIAE SEROTYPE III AND STREPTOCOCCUS PNEUMONIAE SEROTYPE 14: IMPLICATIONS FOR IMMUNOGENICS.
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COMPARISON OF CAPSULAR POLYSACCHARIDE CONFORMATIONS IN STREPTOCOCCUS AGALACTIAE SEROTYPE III AND STREPTOCOCCUS PNEUMONIAE SEROTYPE 14: IMPLICATIONS FOR IMMUNOGENICS.

机译：链球菌血清型III和链球菌血管型血管型血管型血管型血管型血管型14的比较14：免疫学的影响。

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Streptococcus agalactiae (Group B Streptococcus) is a primary cause of neonatal sepsis and meningitis, particularly in infants born to carriers. Streptococcus pneumoniae is another cause of serious infections in young infants, including meningitis and pneumonia. For these bacteria, the capsular polysaccharide (CPS) is essential for bacterial virulence and vaccination with CPS-protein conjugates potentially provides effective serotype-specific protection. Ten serotypes of Group B Streptococcus have been identified, with serotype III (GBSIII) currently the most prevalent [1]. Over 90 serotypes of Streptococcus pneumoniae have been identified; prior to the introduction of conjugate vaccines, Serotype 14 (Pn14) was the most common cause of invasive pneumococcal disease in children [2]. GBSIII is present in conjugate vaccines undergoing clinical trials. The branched CPSs of GBSIII and Pn14 are very similar, differing only in that GBSIII has a terminal sialic acid on the branches. Our new molecular modelling studies provide a rationale for conflicting evidence on the minimal epitopes for GBSIII and Pn14 [3,4]. Simulations of 3- and 6RU oligosaccharide representatives of the GBSIII and Pn14 CPs show a well-defined conformational epitope at the branch point that is absent in the unbranched oligosaccharide. Further, we find that, aside from the branch point, the GBSIII/Pn14 backbone is very flexible with no well-defined conformation. The simulation conformations are supported by NMR NOEs measured for the GBSIII polysaccharide. This work suggests that antibody families recognising the stable, common branch points for GBSIII and Pn14 should show
机译：无乳链球菌（B群链球菌）是新生儿败血症的主要原因和脑膜炎，特别是在出生的婴儿的载体。肺炎链球菌是年轻婴儿发生严重感染的原因，包括脑膜炎和肺炎。对于这些细菌来说，囊状多糖（CPS）对于细菌毒力是必不可少的，并且具有CPS-蛋白质缀合物的疫苗接种可能提供有效的血清型特异性保护。已经鉴定了B组链球菌的10次血清型，血清型III（GBSIII）目前最普遍的[1]。已经确定了90多种链球菌的血清型;在引入缀合物疫苗之前，血清型14（PN14）是儿童侵袭性肺炎球菌疾病最常见的原因[2]。 GBSIII存在于经历临床试验的共轭疫苗中。 GBSIII和PN14的分枝CPS非常相似，仅在GBSIII中具有在分支上具有末端唾液酸的不同。我们的新分子建模研究提供了对GBSIII和PN14的最小表位相互矛盾的互联网的理由[3,4]。的GBSIII和PN14 CP的3-和6RU寡糖代表的模拟显示在分支点是在无支链的寡糖不存在良好定义的构象表位。此外，我们发现，除了分支点之外，GBSIII / PN14骨架非常灵活，没有明确的构象。模拟构象是由GBSIII多糖测量的NMR NOES支持。这项工作表明，抗体家庭认识到GBSIII和PN14的稳定，共同分支点应该表现出来

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