COMPLETE SPATIAL CHARACTERISATION OF A/-GLYCANS IN AN ADULT RAT BRAIN

机译：在成年大鼠脑中完成A / -Glycans的空间表征

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The cardinal role of A/-glycans for the nervous system is brought forth by congenital glycosylation diseases, resulting in different neuropathological symptoms like mental retardation, seizures and epilepsy. Previous studies have reported the conservation of A/-glycan processing in rodents1. However, there is a lack of spatial resolution of these glycan profiles as the tissue samples were homogenized intact for these studies. Since the biosynthesis of N-glycans undergoes a stringent spatio-temporal regulation within the tissue, we hypothesize that the spatial resolution of N-glycans isolated from striatum and substantia nigra can give an insight into their involvement in regulation of striatal and nigral cues for establishment and pathophysiological degeneration of neural circuitry in Parkinson's disease.

机译：通过先天性糖基化疾病提出了神经系统的/糖基因的主要作用，导致智能病理症状不同的神经病理症状，癫痫发作和癫痫。以前的研究报告捕获啮齿动物中的/甘露可加工。然而，由于组织样品完好地为这些研究，存在这些聚糖型材的空间分辨率缺乏空间分辨率。由于N-聚合物的生物合成经历了组织内的严格的时空调节，因此我们假设从纹状体和体内分离的N-Glycans的空间分辨率可以深入了解他们参与其规则的划线和八核线索的规定帕金森病中神经电路的病理生理退化。

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《International Carbohydrate Symposium》|2018年|832 p.|共1页
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Roisin OFlaherty; Juhi Samal; Radka Fahey;
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中图分类碳水化合物、糖;
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COMPLETE SPATIAL CHARACTERISATION OF A/-GLYCANS IN AN ADULT RAT BRAIN

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