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A SYNTHETICALLY DEFINED GLYCOCONJUGATE VACCINE AGAINST CANCER

机译:针对癌症的综合定义的糖醌疫苗

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During the past century, carbohydrate-based vaccines have proven successful against multiple diseases. When conjugated, the glycoconjugate vaccines have some advantages over traditional polysaccharide-based vaccines, such as triggering T cell dependent responses and the possibility of being used to immunize children under five years of age. With this in mind, a three-component vaccine composed of designed MUC1 glycopeptide derivatives (antigen), OVA257-264 (to act as an adjuvant) and PEGylated Gold Nanoparticles (to act as carriers) was developed.
机译:在过去的世纪中,基于碳水化合物的疫苗已被证明是针对多种疾病的成功。当缀合时,糖醌疫苗对传统的多糖基疫苗具有一些优点,例如触发T细胞依赖性反应以及用于免疫五岁以下儿童的可能性。考虑到这一点,由设计的Muc1糖肽衍生物(抗原),OVA257-264(以用作佐剂)和聚乙二醇化金纳米颗粒(以用作载体)组成的三组分疫苗。

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