HOMOGENEOUS ANTIBODY-DRUG CONJUGATE PREPARATION VIA GLYCAN LINKAGE

机译：通过聚糖键合的均相抗体 - 药物缀合物制备

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Antibodies usually have an N-glycan moiety at the Asn297 in the Fc region. Glycans of antibodies are usually heterogeneous, and non-human-type glycans have immunogenicity. It is also known that the glycan structure of antibodies influences antibody-dependent cell-mediated cytotoxicity (ADCC).

机译：抗体通常在Fc区的ASN297处具有N-聚糖部分。抗体的聚糖通常是异质的，非人型聚糖具有免疫原性。还已知抗体的聚糖结构影响抗体依赖性细胞介导的细胞毒性（ADCC）。

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《International Carbohydrate Symposium》|2018年|832 p.|共1页
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Shino Manabe; Yoshiki Yamaguchi; Kana Matsumoto;
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中图分类碳水化合物、糖;
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1. Characterization of Antibody Products Obtained through Enzymatic and Nonenzymatic Glycosylation Reactions with a Glycan Oxazoline and Preparation of a Homogeneous Antibody-Drug Conjugate via Fc N-Glycan [J] . Manabe Shino, Yamaguchi Yoshiki, Matsumoto Kana, Bioconjugate Chemistry . 2019,第5期

机译：通过酶促和非酶糖基化反应获得的抗体产物的表征通过甘油恶唑啉，并通过Fc N-聚糖制备均相抗体 - 药物缀合物的制备
2. Glycan-Mediated Technology for Obtaining Homogeneous Site-Specific Conjugated Antibody-Drug Conjugates: Synthesis and Analytical Characterization by Using Complementary Middle-up LC/HRMS Analysis [J] . Duivelshof Bastiaan L., Desligniere Evolene, Hernandez-Alba Oscar, Analytical chemistry . 2020,第12期

机译：聚糖介导的技术获得均相现位特异性缀合的抗体 - 药物缀合物：通过使用互补的中升LC / HRMS分析来合成和分析表征
3. Chemoenzymatic Conjugation of Toxic Payloads to the Globally Conserved N-Glycan of Native mAbs Provides Homogeneous and Highly Efficacious Antibody-Drug Conjugates [J] . van Geel Remon, Wijdeven Marloes A., Heesbeen Ryan, Bioconjugate Chemistry . 2015,第11期

机译：毒性负载的化学酶结合到天然单克隆抗体的全球保守N-聚糖上提供了均一且高效的抗体-药物结合物
4. HOMOGENEOUS ANTIBODY-DRUG CONJUGATE PREPARATION VIA GLYCAN LINKAGE [C] . Shino Manabe, Yoshiki Yamaguchi, Kana Matsumoto International Carbohydrate Symposium . 2018

机译：通过聚糖键合的均相抗体 - 药物缀合物制备
5. A New Hybrid Agent-Based Model to Evaluate Antibody-Drug Conjugates in Solid Tumors [D] . Menezes, Bruna. 2021

机译：基于杂种代理的基于模型，以评估固体瘤中的抗体 - 药物缀合物
6. Harnessing a catalytic lysine residue for the one-step preparation of homogeneous antibody-drug conjugates [O] . Alex R. Nanna, Xiuling Li, Even Walseng, -1

机译：利用催化赖氨酸残基一步制备均质抗体-药物偶联物
7. Harnessing a catalytic lysine residue for the one-step preparation of homogeneous antibody-drug conjugates [O] . Alex R. Nanna, Xiuling Li, Even Walseng, 2017

机译：利用催化赖氨酸残基进行均匀抗体 - 药物缀合物的一步制备

HOMOGENEOUS ANTIBODY-DRUG CONJUGATE PREPARATION VIA GLYCAN LINKAGE

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