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SYNTHESIS OF THE REPEATING UNIT OF GROUP B STREPTCOCCUS SEROTYPE IV CAPSULAR POLYSACCHARIDE USING GLYCONEER AUTOMATED GLYCAN SYNTHESIZER

机译:使用甘油膜自动化甘油合成器合成B组链霉菌血清型IV荚膜多糖的重复单元

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摘要

Specific recognition of bacterial polysaccharides is the basis of their application for developing conjugate vaccines. Oligosaccharides for vaccine production are typically obtained by fragmentation of polysaccharides extracted from bacterial cultures. This method provides complex mixtures of oligosaccharides with different chemical identities. Chemical synthesis allows the preparation of chemically pure samples of target oligosaccharides and therefore allows a variety of protein-carbohydrate interaction methodologies to be applied.
机译:细菌多糖的特异性识别是它们用于显影缀合物疫苗的应用的基础。用于疫苗产生的寡糖通常通过从细菌培养物中提取的多糖的破碎来获得。该方法提供了具有不同化学本标识的寡糖混合物。化学合成允许制备靶寡糖的化学纯样品,因此允许应用各种蛋白质 - 碳水化合物相互作用方法。

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