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SYNTHESIS OF BIOACTIVE GLYCOPEPTIDES AND NEOGLYCOPEPTIDES USING SOLID PHASE PEPTIDE SYNTHESIS, NATIVE CHEMICAL LIGATION, CLICK CHEMISTRY AND ENZYMATIC GLYCOSYLATION

机译：使用固相肽合成，天然化学结扎，点击化学和酶促糖基合成生物活性糖肽和新胶肽的合成

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Novel chemical methods to access homogeneous samples of glycopeptides and glycoproteins have developed rapidly in recent years owing to an increased need to investigate both their roles in molecular biology and their potential as therapeutic agents. Glycopeptide and glycoprotein mimetics with non-native linkages, so-called neoglycopeptides and neoglycoproteins respectively, are often readily accessible and usually available as a single neoglycoform.

机译：近年来，由于需要调查其分子生物学的作用及其作为治疗剂的潜力，近年来，近年来近年来进入糖肽和糖蛋白的均匀样品的新化学方法迅速发展。糖肽和糖蛋白模拟物分别具有非天然键，所谓的新葡萄肽和新葡萄糖蛋白，通常易于易于获得，通常可用作单个新糖型。

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《International Carbohydrate Symposium》|2018年|832 p.|共1页
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Margaret A. Brimble;
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中图分类碳水化合物、糖;
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1. Solid-Phase Synthesis of Peptide C-Terminal Thioesters by Fmoc/t-Bu Chemistry; Fmoc-Based Synthesis of Peptide-α-Thioesters: Application to the Total Chemical Synthesis of a Glycoprotein by Native Chemical Ligation [J] . Anna Bernardi, Leonardo Manzoni Chemtracts . 2000,第9期

机译：用Fmoc / t-Bu化学方法固相合成肽C-末端硫代酸酯;基于Fmoc的肽-α-硫代酸酯的合成：通过天然化学连接在糖蛋白的总化学合成中的应用
2. An Orthogonal Double-Linker Resin Facilitates the Efficient Solid-Phase Synthesis of Complex-Type N-Glycopeptide Thioesters Suitable for Native Chemical Ligation [J] . Stefano Mezzato, Manuela Schaffrath, Carlo Unverzagt Angewandte Chemie . 2005,第11期

机译：正交双接头树脂有助于适用于天然化学连接的复杂型N-糖肽硫酸酯的高效固相合成
3. A Designed Well-Folded Monomeric Four-Helix Bundle Protein Prepared by Fmoc Solid-Phase Peptide Synthesis and Native Chemical Ligation [J] . Gunnar T.Dolphin Chemistry: A European journal . 2006,第5期

机译：Fmoc固相肽合成和天然化学连接制备的设计良好折叠的单体四螺旋束蛋白
4. SYNTHESIS OF BIOACTIVE GLYCOPEPTIDES AND NEOGLYCOPEPTIDES USING SOLID PHASE PEPTIDE SYNTHESIS, NATIVE CHEMICAL LIGATION, CLICK CHEMISTRY AND ENZYMATIC GLYCOSYLATION [C] . Margaret A. Brimble International Carbohydrate Symposium . 2018

机译：使用固相肽合成，天然化学结扎，点击化学和酶促糖基合成生物活性糖肽和新胶肽的合成
5. A photolabile backbone amide linker for the solid-phase synthesis of cyclic peptides. Cysteine-free native chemical ligation. Synthesis and biological evaluation of a library of resveratrol analogues. [D] . Kang, Soo Sung. 2009

机译：光不稳定的主链酰胺接头，用于固相合成环状肽。无半胱氨酸的天然化学连接。白藜芦醇类似物文库的合成和生物学评估。
6. Combining triazole ligation and enzymatic glycosylation on solid phase simplifies the synthesis of very long glycoprotein analogues [O] . Mathieu Galibert, Véronique Piller, Friedrich Piller, 2015

机译：在固相上结合三唑连接和酶促糖基化可简化非常长的糖蛋白类似物的合成
7. Combining triazole ligation and enzymatic glycosylation on solid phase simplifies the synthesis of very long glycoprotein analogues [O] . Galibert, Mathieu, Piller, Véronique, Piller, Friedrich, 2015

机译：在固相上结合三唑连接和酶促糖基化可简化非常长的糖蛋白类似物的合成

SYNTHESIS OF BIOACTIVE GLYCOPEPTIDES AND NEOGLYCOPEPTIDES USING SOLID PHASE PEPTIDE SYNTHESIS, NATIVE CHEMICAL LIGATION, CLICK CHEMISTRY AND ENZYMATIC GLYCOSYLATION

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