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首页> 外文会议>IEEE Nuclear Science Symposium >Design for a High-resolution Small-Animal SPECT 125{sup left}I System Using Pixellated Si(Li) Detectors for In Vivo 125{sup left}I Imaging
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Design for a High-resolution Small-Animal SPECT 125{sup left}I System Using Pixellated Si(Li) Detectors for In Vivo 125{sup left}I Imaging

机译：使用像素化Si（Li）vivo 125 {sup left} imagings的系统中的高分辨率小动物Spect 125 {sup left} .I

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We propose a design for a high-resolution SPECT system for in vivo 125{sup left}I imaging in small animal using pixcllated lithium-drifted silicon (Si(Li)) detectors. The detectors have high detection efficiency (> 90%), good energy resolution (< 15% FWHM), and good intrinsic spatial resolution (～ 1 mm FWHM). The SPECT system has a dual head detector geometry with the distance between the detectors ranging 30-50 mm to allow for the shortest imaging distance between the mouse and the detectors. The detectors, each with an active area of 64 mm × 40mm (64 ×40 array of 1 mm{sup}2 pixels and a 6 mm thick Si(Li) detector), are mounted on a rotating gantry with an axial field-of-view of 64 mm. Using a high-resolution parallel-hole collimator, the expected spatial resolution is 1.6 mm FWHM at an imaging distance of 20 mm, and sensitivity is 6.7 cps/μCi. 125{sup left}I is a readily available radioisotope with a long half-life of 59.4 days and it is commonly used to label biological compounds in molecular biology. Conventional gamma cameras are not optimized to detect the low emission energies (27 to 35 keV) of 125{sup left}I. However, Si(Li) detector provides an ideal solution for detecting the low-energy emissions of 125{sup left}I. In addition, a SPECT system based on Si(Li) detector can potentially be less expensive than other detector technology because of its ease of operation and the availability of many resources for processing silicon. This will increase the availability of small-animal SPECT systems in biomedical research, thereby providing an important tool to facilitate the research in mouse biology.
机译：我们向使用PIXCLATED锂漂移的硅（SI（LI））探测器的小型动物进行了高分辨率SPECT系统，为vivo 125 {sup左} i成像设计了一种设计。探测器具有高检测效率（> 90％），能量分辨率良好（<15％FWHM）和良好的内在空间分辨率（〜1mm FWHM）。 SPECT系统具有双头检测器几何形状，检测器之间的距离范围为30-50mm，以允许鼠标和检测器之间的最短成像距离。具有64mm×40mm（64×40阵列为1mm×4} 2像素的64×40mm×2像素和6mm厚的Si（Li）检测器）的探测器安装在旋转架上，轴向场 - 介于64毫米。使用高分辨率平行孔准直器，预期的空间分辨率在20mm的成像距离处为1.6 mm fwhm，灵敏度为6.7 cps /μci。 125 {sup left}我是一个易于获得的放射性同位素，长期半衰期为59.4天，通常用于标记分子生物学中的生物化合物。不优化常规的伽马摄像机以检测125 {sup left} i的低发射能量（27到35kev）。然而，Si（Li）检测器提供了一种理想的解决方案，用于检测125 {SUP左} I的低能量排放。此外，基于Si（Li）检测器的SPECT系统可能比其他检测器技术易于昂贵，因为它易于操作和许多用于处理硅的资源的可用性。这将提高生物医学研究中小动物SPECT系统的可用性，从而提供了促进小鼠生物学研究的重要工具。

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