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首页> 外文会议>Interdisciplinary Congress of the Hellenic Society for the Advancement ofPsychiatry and Related Sciences >Hypothalamus-Pituitary-Adrenal Axis Activity, And Neurocognitive Functioning In Bipolar Disorder: A Preliminary Report
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Hypothalamus-Pituitary-Adrenal Axis Activity, And Neurocognitive Functioning In Bipolar Disorder: A Preliminary Report

机译：双相障碍中下丘脑 - 垂体 - 肾上腺轴活性和神经认知功能：初步报告

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摘要

Bipolar disorder is associated with neuropsychological impairment in various cognitive domains but the aetiology of such impairment remains largely unknown. Previous research has speculated that Hypothalamus-Pituitary-Adrenal (HPA) axis dysregulation may be a contributing factor. In the present study we evaluated the performance of 60 bipolar I patients in various cognitive tasks targeting attention, visual memory and executive function within the framework of the HPA axis hyperactivity model. We present here some preliminary results. Basal cortisol significantly correlated with visual memory as well as with planning and problem solving (i.e. high cortisol levels corresponded to lower test scores) whereas no statistically significant difference was observed between cognitive measures of suppressors and non suppressors at the Dexamethasone Suppression Test (DST).
机译：双极性障碍与各种认知结构域中的神经心理障碍有关，但这种损害的病因仍然很大程度上是未知的。以前的研究推测，下丘脑 - 垂体 - 肾上腺（HPA）轴缺陷剂量可能是贡献因子。在本研究中，我们评估了在HPA轴多动模型的框架内定位的各种认知任务中的60个双极I患者的性能。我们在这里展示一些初步结果。基础皮质醇与可视记忆以及规划和问题求解显着相关（即，高皮质醇水平相对应较低的试验评分），而在地塞米松抑制试验（DST）的抑制剂和非抑制器的认知措施之间没有观察到统计学上显着差异。

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