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首页> 外文会议>Granada Seminar on Computational and Statistical Physics >The emergence of spontaneous activity in neuronal cultures
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The emergence of spontaneous activity in neuronal cultures

机译：神经元培养中自发活性的出现

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摘要

In vitro neuronal networks of dissociated hippocampal or cortical tissues are one of the most attractive model systems for the physics and neuroscience communities. Cultured neurons grow and mature, develop axons and dendrites, and quickly connect to their neighbors to establish a spontaneously active network within a week. The resulting neuronal network is characterized by a combination of excitatory and inhibitory neurons coupled through synaptic connections that interact in a highly nonlinear manner. The nonlinear behavior emerges from the dynamics of both the neurons' spiking activity and synaptic transmission, together with biological noise. These ingredients give rise to a rich repertoire of phenomena that are still poorly understood, including the emergence and maintenance of periodic spontaneous activity, avalanches, propagation of fronts and synchronization. In this work we present an overview on the rich activity of cultured neuronal networks, and detail the minimal theoretical considerations needed to describe experimental observations.
机译：分离的海马或皮质组织的体外神经元网络是物理和神经科学社区最具吸引力的模型系统之一。培养的神经元生长和成熟，开发轴突和树突，并迅速连接到邻居，在一周内建立自发的活跃网络。所得到的神经元网络的特征在于通过以高度非线性方式相互作用的突触连接的兴奋性和抑制神经元的组合。非线性行为从神经元尖峰活动和突触传递的动态出现，以及生物噪声。这些成分引起了尚未理解的现象的丰富的现象，包括出现和维持周期性的自发性活动，雪崩，前方传播和同步。在这项工作中，我们概述了培养的神经网络的丰富活动，并详细说明了描述实验观察所需的最小理论考虑因素。

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