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首页> 外文会议>Annual Applied Science and Engineering Conference >Induction of Toll-like receptor (TLR) 2 and Myeloid88-dependent TLR-Signaling Response to Aeromonas Hydrophila Infections in Gouramy (Osphronemus Gouramy)
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Induction of Toll-like receptor (TLR) 2 and Myeloid88-dependent TLR-Signaling Response to Aeromonas Hydrophila Infections in Gouramy (Osphronemus Gouramy)

机译：诱导Toll样受体（TLR）2和Myeloid88依赖性TLR信号传导反应对植物（Quapromus植物）的AeroMonas疏水液感染

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Toll-like receptors (TLRs) are a family of innate immune receptors that recognize molecular patterns associated with microbial pathogens (PAMP) and induce antimicrobial immune responses. Here we report the expression of TLR2, Myeloid differentiation primary response gene 88 (Myd88) and Interleukin 1beta (IL1β) from the Gouramy an economically freshwater fish in Indonesia. Upon stimulation with Aeromonas hydrophila, the TLR2 expression was obviously up-regulated in spleen and liver, Myd88 expression up-regulated in spleen and kidney, and IL1β expression was up-regulated in a spleen, kidney, and liver. The highest expression of TLR2 was in liver or hepatopancreas, MyD88 in kidney and IL1β was in the spleen. These findings together highlighted the contribution of TLR2 in augmenting innate immunity in fish and indicated its important role in immune surveillance of various organs during the pathogenic invasion. This study will enrich the information in understanding the innate immune mechanism in fish and will be helpful in developing preventive measures against infectious diseases in fish.
机译：Toll样受体（TLR）是一系列先天免疫受体，其识别与微生物病原体（PAMP）相关的分子模式并诱导抗菌免疫应答。在这里，我们在印度尼西亚的经济上淡水鱼中报告TLR2，骨髓分化初级反应基因88（MYD88）和白细胞介素1Beta（IL1β）的表达。在刺激Aeromonas疏水中时，TLR2表达在脾脏和肾脏上调的脾脏和肝脏中明显上调，IL1β表达在脾，肾和肝中上调。 TLR2的最高表达在肝脏或肝癌中，肾脏和IL1β中的MyD88是脾脏。这些调查结果突出了TLR2在鱼类中增强先天免疫力的贡献，并表明了在致病侵袭过程中免疫监测中的重要作用。本研究将丰富了解鱼类的天生免疫机制，并有助于制定对鱼类传染病的预防措施。

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