• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Health Science International Conference >The Role of Probiotics in Inflammatory Responses of Critically-Ill Burn Patients (A Randomized Clinical Trial)
【24h】

The Role of Probiotics in Inflammatory Responses of Critically-Ill Burn Patients (A Randomized Clinical Trial)

机译：益生菌在危险性烧伤患者炎症反应中的作用（随机临床试验）

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Impairment of intestinal barrier function and increased translocation of bacteria to the systemic blood flow contribute to the emergence of sepsis in burn patients. Oral probiotic administration has been advocated for treatment and prevention of diverse range of infection disease by modulating the host immune reponse. Objectives: This research was to determine the effect of probiotics containing Lactobacillus and Bifidobacterium on leucocyte and neutrophil level and on the clinical outcome in burn patients. Methods: Seventeen burn patients with burns involving more than 15% total body surface area were randomized in a prospective, double-blind, non-placebo, assigned to receive mono and multistrain probiotics (Lactobaccilus and Bifidobacteria) once daily for consecutive fourteen days. Laboratory measurements of Leucocyte and Neutrophil were done on days 4 dan 19. Clinical outcomes including incidence of diarrhea, infection, and mortality were also recorded. Results: There was no incidence of diarrhea and incidence of sepsis and also mortality were similiar between two groups during this study. Multistrain probiotics reduced significant level both of leucocytes and neutrophil during this study (P < 0,05) with significant differences between two groups only in neutrophil level. Conclusion: Administration of monostrain and multistrain probiotics to burn patients caused better clinical outcomes and reduced level of inflammatory parameters (leucocyte and neutrophil). It might be considered as an adjunctive therapy in the treatment of burn patients to treat infection.
机译：背景：肠道阻隔功能的损害和增加细菌的易位对全身血流有助于烧伤患者脓毒症的出现。通过调节宿主免疫应答，提倡口服益生菌局进行治疗和预防各种感染疾病。目的：该研究是确定益生菌含有乳酸杆菌和双歧杆菌对白细胞和中性粒细胞水平的影响以及烧伤患者的临床结果。方法：涉及超过15％的烧伤患者，涉及超过15％的体表面积的烧伤，在前瞻性的双盲，非安慰剂中随机分配，分配给每天一次每天服用Mono和MultiStrain益生菌（乳杆菌和双歧杆菌），连续十四天。还记录了白细胞和嗜中性粒细胞的实验室测量。还记录了包括腹泻，感染和死亡率的临床结果，包括腹泻，感染和死亡率的临床结果。结果：腹泻的发生率和脓毒症发病率，并且在本研究期间两组之间的死亡率也是如此。多水土益生菌在本研究期间的白细胞和中性粒细胞两组（P <0.05）中的显着水平降低，两组仅在中性粒细胞水平之间具有显着差异。结论：给予单血管和多水土益生菌的烧伤患者患者均致力于临床结果，降低炎症参数（白细胞和中性粒细胞）。它可能被认为是治疗烧伤患者治疗感染的辅助治疗。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号