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首页> 外文会议>International Symposium of Biomedical Engineering >The experiment of magnesium ECAP miniplate as alternative biodegradable material (on male white New Zealand rabbits)
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The experiment of magnesium ECAP miniplate as alternative biodegradable material (on male white New Zealand rabbits)

机译：镁Ecap Miniplate作为替代生物降解材料的实验（在雄性白色新西兰兔子）

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Study of biodegradations of Magnesium ECAP (Equal Channel Angular Pressing) miniplate in the osteosynthesis system has been used as a new material for plate and screw in oral and maxillofacial surgery. This miniplate and screw that were made of Magnesium ECAP were implanted in the femurs of New Zealand rabbits. The degradation process was detected through pocket gas that appeared in hard and soft tissues surrounding in the implanted miniplates and screws. From the changes on the tissues, we can assess the biodegradation process by measuring the gas pocket through micro-CT Scan. Upon the first month of study we euthanized the rabbits and made a micro-CT Scan to see how far the effect of the gas pocket was. Histological analyses were performed to investigate the local tissue response adjacent to the Magnesium ECAP miniplates. We analyzed the femur of a rabbit a month, three months, and five months after implantation. The result showed a degradation rate in the implanted Magnesium ECAP miniplate of 0.61±0.39 mm/year. Unlike the screws, miniplates have higher water content and blood flow than bone, therefore they degrade faster. This study shows promising results for further development of Magnesium ECAP and in the production of osteosynthesis material for rigid fixation in Oral and Maxillofacial skeleton.
机译：在骨糖合成系统中的镁型Ecap（等通道角度压制）微型板的生物降解已被用作口腔和颌面外科的板和螺钉的新材料。这种由镁Ecap制成的螺杆植入新西兰兔的股骨。通过在植入的小柱状和螺钉中出现的袋和软组织中出现的袋气和软组织中的袋气来检测降解过程。根据组织的变化，我们可以通过通过微CT扫描测量气体口袋来评估生物降解过程。在研究的第一个月后，我们安乐死了兔子并制作了微型CT扫描，看看气口的效果有多远。进行组织学分析以研究与镁Ecap势率相邻的局部组织响应。我们分析了一个月，三个月和植入后五个月的兔子的股骨。结果显示植入镁Ecap小块的降解速率为0.61±0.39mm /级。与螺钉不同，小柱具有更高的水含量和血流而不是骨骼，因此它们更快地降低。本研究表明，进一步发展镁Ecap的进一步发展以及在口腔和颌骨骨架中刚性固定的骨质合成材料的生产。

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