• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>International Symposium of Biomedical Engineering >High Progesterone Levels on the Day of hCG Administration in Controlled Ovarian Hyperstimulation Procedures Reduce the Expression of Progesterone Receptors in the Endometrium Macaca nemestrina
【24h】

High Progesterone Levels on the Day of hCG Administration in Controlled Ovarian Hyperstimulation Procedures Reduce the Expression of Progesterone Receptors in the Endometrium Macaca nemestrina

机译：在受控卵巢过度刺激手术中HCG给药当天的高孕酮水平降低了胚胎麦卡纳涅什蒂纳内膜中黄体酮受体的表达

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Progesterone (P4) increases on the day of hCG administration in Controlled Ovarian Hyperstimulation (COH) procedure has reduced the rate of pregnancy in Assisted Reproductive Technology (ART). The aim of the study was to analyze the effect of the increase in P4 on the day of hCG administration to the expression of progesterone receptor (PR). Method: 15 samples of Macaca nemestrina endometrial tissue, in the form of stored biological materials, originated from groups of natural cycles and cycles stimulated in the COH procedure. For 16 endometrial tissue samples, PR expression was measured by immunohistochemical (CPI) technique. The level of PR expression was compared between the natural cycle and the stimulated cycle that got P4>1 ng/mL and P4 <1 ng/mL. Results: PR expression was detected in three endometrial compartments, which were glandular cells, epithelial luminal cells and stroma. Semi-quantitative analysis used the formula H_SCORE = Σpi (i + 1). PR expression in the gland epithelium from natural cycle group and stimulated cycle with P4>1 ng / mL and P4 1 ng / mL in the stimulated cycle, it did not differ statistically (P > 0.05). Then, PR expression between P4 in the natural cycle with P4 <1 ng / mL in the stimulated cycle there was no significantly different (P > 0.05). PR expression in the luminal epithelium and stroma, between natural cycles and stimulated cycles was also not significantly different (P> 0.05). Conclusion, the level of P4 > 1 ng / mL on the day of administration of hCG in the COH procedure decreases PR expression in the endometrial gland.
机译：孕酮（P4）在受控卵巢过度刺激（COH）中的HCG给药日的增加（COH）程序降低了辅助生殖技术（ART）的妊娠率。该研究的目的是分析HCG施用当天增加P4的影响，以表达孕酮受体（PR）。方法：15种麦卡纳奈斯坦林组织样品，以储存的生物材料的形式起源于在COH过程中刺激的天然循环和循环组。对于16个子宫内膜组织样品，通过免疫组织化学（CPI）技术测量PR表达。在自然循环和受刺激的循环之间比较PR表达的水平，得到P4> 1 ng / ml和P4 <1ng / ml。结果：在三个子宫内膜隔间中检测到PR表达，其是腺体细胞，上皮腔细胞和基质。半定量分析使用公式H_Score =ΣPI（I + 1）。从天然循环组和P4> 1ng / ml和p4 0.05）。然后，在刺激循环中的P4 <1ng / ml的自然循环中P4之间的PR表达没有显着不同（P> 0.05）。在腔上皮和基质中的PR表达，在天然循环和刺激的循环之间也没有显着差异（P> 0.05）。结论，COH过程中HCG当天P4> 1ng / ml的水平降低了子宫内膜腺体中的PR。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号