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首页> 外文会议>International Symposium of Biomedical Engineering >Total Phenolic, UPLC-QTOF-MS Analysis and Antidepressant-like Effect in The Mice Forced Swim Test of Jamu Neuropathic Pain Reducer
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Total Phenolic, UPLC-QTOF-MS Analysis and Antidepressant-like Effect in The Mice Forced Swim Test of Jamu Neuropathic Pain Reducer

机译：在Jamu神经病变减速剂的小鼠强制游泳试验中，全酚类酚类，UPLC-QTOF-MS分析和抗抑郁效果

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摘要

Neuropathic (nerve) pain is caused by damage, dysfunction or injury of nerves it will affect patient's quality of life because of chronicity and intensity. The pharmaceutical drug commonly used to treat neuropathic pain is antidepressants. However, Anti-depressant drug has dangerous side effects if consumed continuously. Herbs treatments use throughout the world for the treatment of neuropathic pain. Jamu Neuropathic Pain Reducer, which consists of aqueous multi herbs extract of nutmeg seed (Myristica fragrans), clove bud (Syzygium aromaticum) and red ginger rhizome (Zingiber officinale var rubrum) was extracted with variation temperature (60, 80, 100°C). This study aimed to figure out the total phenolic content (TPC) in the Jamu Neuropathic Pain Reducer used the Folin-Ciocalteu method. The highest TPC (33.58±1.473mg GAE/g herb) happened at temperature 80°C UPLC-QTOF-MS applied to identify the major bioactive compound in Jamu Neuropathic Pain Reducer extract used temperature extraction 80°C, analysis revealed the presence of compounds such as adenine, chlorogenic acid, miquelianin, quercitrin, 6-gingerol, myristicin, and eugenol. Jamu Neuropathic Pain Reducer reduced the immobility duration compared with the control negative (distilled water) (p<0.001). The reductions of the immobility time were 8.3%, 36.4% and 30.1% for dosage 16.25 mL/kg, 32.5 mL/kg and 65 mL/kg, therefore, Jamu Neuropathic Pain Reducer had the potential to be an alternative as herbal medicine for neuropathic pain that less expensive and has minimum side effect.
机译：神经疗法（神经）疼痛是由损伤，功能障碍或神经损伤引起的，由于慢性和强度，它会影响患者的生活质量。常用于治疗神经病疼痛的药物是抗抑郁药。然而，如果连续消耗，抗抑郁药物具有危险的副作用。草药治疗在世界各地使用治疗神经病疼痛。由肉豆蔻种子（MyRistica Fragrans）的水性多草药提取物组成的Jamu神经病理疼痛还原剂，用变化温度（60,80,100°C）提取丁香芽（Syzygium aromaticum）和红色姜根茎（Zingiber Officinale Var Rubrum） 。本研究旨在弄清楚JAMU神经性疼痛减速器中的总酚类含量（TPC）使用Folin-Ciocalteu方法。最高的TPC（33.58±1.473mg Gae / g Herb）在施用的温度80°C-QTOF-MS中施加，以鉴定Jamu神经病变减速剂提取物使用的温度萃取80°C，分析显示化合物的存在如腺嘌呤，绿原酸，咪塞氏素，槲皮素，6-姜，肉豆蔻蛋白和丁香酚。与控制负（蒸馏水）相比，Jamu神经性疼痛减速剂降低了不动持续时间（P <0.001）。剂量为10.3％，36.4％和30.1％的减少量16.25ml / kg，32.5ml / kg和65ml / kg，因此，Jamu神经性疼痛减速剂有可能成为神经治疗的草药疼痛较便宜并且具有最小副作用。

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